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Efficacy of longterm interferon treatment in chronic liver disease evaluated by sensitive polymerase chain reaction assay for hepatitis C virus RNA.

Author: HosodaK, ImazekiF, ItoY, KatoN, OhtoM, OmataM, YokosukaO

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

In a study of 70 people with chronic liver disease caused by hepatitis C, those who received long-term interferon treatment (52 weeks) had a much higher rate of normalized liver enzymes and undetectable hepatitis C virus compared to those who received short-term treatment (8 weeks) or placebo. Long-term interferon treatment was effective in clearing the virus from the blood in 12 out of 21 patients, and this remained undetectable for 3 years after treatment.
Paper Details　
Original Abstract of the Article :
Effects of interferon treatment on hepatitis C virus were examined by investigating the presence of hepatitis C virus ribonucleic acid and anti-hepatitis C virus antibody in 70 patients with non-A, non-B chronic liver diseases. Twenty one patients were treated with three million units of interferon ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://doi.org/10.1136/gut.37.5.721

データ提供：米国国立医学図書館（NLM）

Long-Term Interferon Treatment: A Oasis in the Hepatitis C Desert

Hepatitis C is a persistent and challenging disease, like a relentless desert wind that can cause lasting damage. Scientists are constantly searching for ways to control this viral infection, and this study investigated the efficacy of long-term interferon treatment in patients with chronic liver disease caused by hepatitis C. The researchers used a sensitive polymerase chain reaction assay to detect the presence of hepatitis C virus RNA, a key indicator of viral activity, in patients receiving interferon treatment. The results demonstrated that long-term interferon treatment was significantly more effective than short-term treatment or placebo in clearing the virus from the bloodstream, offering a potential oasis in the desert of hepatitis C infection.

A More Sustainable Oasis in the Hepatitis C Desert

The study showed that long-term interferon treatment resulted in a normalization of alanine aminotransferase (ALT) activity and undetectable levels of hepatitis C virus RNA in a significant proportion of patients. This indicates that long-term interferon treatment can effectively clear the virus, offering a more sustainable oasis in the hepatitis C desert.

Navigating the Hepatitis C Desert with Treatment

This research emphasizes the importance of adhering to a long-term treatment plan for hepatitis C. The study's findings suggest that long-term interferon treatment can effectively clear the virus from the bloodstream, preventing the development of serious complications. It's essential to consult with a healthcare professional to discuss the best treatment options for your individual needs.

Dr. Camel's Conclusion

This study offers a glimmer of hope in the desert of hepatitis C infection, demonstrating the potential of long-term interferon treatment to effectively clear the virus from the bloodstream. This research highlights the importance of adhering to a long-term treatment plan, offering a pathway to a more sustainable oasis in the desert of hepatitis C.

Date :
  1. Date Completed 1996-02-20
  2. Date Revised 2019-05-01
Further Info :

Pubmed ID

8549952

DOI: Digital Object Identifier

10.1136/gut.37.5.721

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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