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Effect of tamoxifen on bone mineral density measured by dual-energy x-ray absorptiometry in healthy premenopausal and postmenopausal women.

Author: AshleyS, HickishT, KanisJ A, PowlesT J, TidyA

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tamoxifen treatment is associated with a significant loss of BMD in premenopausal women, whereas it prevents bone loss in postmenopausal women.
Paper Details　
Original Abstract of the Article :
PURPOSE: Tamoxifen is an effective treatment for metastatic and primary breast cancer and is now being evaluated as a chemoprevention agent in healthy women. Any long-term effects on estrogen-sensitive tissues such as bone may have important therapeutic implications. METHODS: We measured bone miner...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://doi.org/10.1200/JCO.1996.14.1.78

データ提供：米国国立医学図書館（NLM）

Tamoxifen's Dual Roles: Friend or Foe to Bone Health?

This research takes us on a journey into the fascinating world of tamoxifen, a medication widely used to treat breast cancer. Like a desert explorer navigating the shifting sands of a challenging landscape, the researchers examined the impact of tamoxifen on bone mineral density in healthy premenopausal and postmenopausal women. They used dual-energy x-ray absorptiometry (DXA), a powerful tool for assessing bone health, to unveil the intricate effects of tamoxifen on bone metabolism.

Tamoxifen: A Balancing Act in Bone Metabolism

The researchers discovered a fascinating duality in tamoxifen's influence on bone health. In premenopausal women, like a desert wind eroding the landscape, tamoxifen led to a progressive decline in bone mineral density. However, in postmenopausal women, tamoxifen acted as a protector, preventing bone loss. This intriguing finding highlights the complex interplay between tamoxifen, estrogen, and bone metabolism.

Navigating the Landscape of Bone Health

The research underscores the importance of understanding the nuanced effects of tamoxifen on bone health. For premenopausal women, the potential for bone loss is a crucial consideration, while postmenopausal women may benefit from the bone-preserving effects of tamoxifen. This study provides valuable insights for healthcare professionals and individuals considering tamoxifen treatment, emphasizing the need for personalized approaches to ensure optimal health outcomes.

Dr. Camel's Conclusion

Tamoxifen's influence on bone health, like a shifting mirage in the desert, reveals a complex interplay of factors. This research offers a valuable roadmap for understanding and managing bone health in women undergoing tamoxifen treatment. As a researcher, I am particularly fascinated by the contrasting effects of tamoxifen on premenopausal and postmenopausal women. This discovery underscores the importance of personalized medicine and the need to tailor treatment strategies to each individual's unique needs.

Date :
  1. Date Completed 1996-02-23
  2. Date Revised 2022-03-31
Further Info :

Pubmed ID

8558225

DOI: Digital Object Identifier

10.1200/JCO.1996.14.1.78

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・Effects of tamoxifen
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PICO Info
in preparation
Languages

English

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