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Diethylpropion pharmacotherapeutic adjuvant therapy for inpatient treatment of cocaine dependence: a test of the cocaine-agonist hypothesis.

Author: AlimT N, DeutschS I, LindquistT, RosseR B, VocciF J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Diethylpropion was not found to be more effective than placebo in attenuating cocaine cue-induced craving in cocaine-dependent patients. This study confirmed earlier reports that craving for cocaine diminishes during inpatient hospitalization. Although diethylpropion was not effective, the study demonstrates that the cocaine cue-induced craving paradigm is effective in stimulating craving for cocaine.
Paper Details　
Original Abstract of the Article :
Fifty cocaine-dependent patients completed a 2-week double-blind, double-dummy, parallel-group comparison of four dosage levels of diethylpropion and placebo. This clinical trial was designed to evaluate both diethylpropion's ability to attenuate cocaine cue-induced craving and its potential for dev...See full text at original site
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引用元：
https://doi.org/10.1097/00002826-199504000-00009

データ提供：米国国立医学図書館（NLM）

Diethylpropion: A Quest for a New Treatment for Cocaine Dependence

The field of addiction medicine is constantly searching for effective treatments for substance use disorders, including cocaine dependence. This study explores the potential of diethylpropion, a medication used for weight loss, as a treatment for cocaine dependence. The researchers conducted a clinical trial to evaluate diethylpropion's efficacy in attenuating cocaine cue-induced craving.

A Challenging Quest in the Desert of Addiction

The study, like a journey through a vast and unforgiving desert, reveals the complexities of treating cocaine dependence. The researchers found that diethylpropion did not demonstrate significant efficacy in reducing cocaine craving compared to placebo. This finding highlights the challenges of developing effective treatments for this complex and often debilitating addiction. It's like searching for a hidden oasis in the desert, where the path is long and arduous, and success is not guaranteed.

Continued Research: A Need for New Approaches

This study, while not yielding positive results for diethylpropion, emphasizes the ongoing need for research into new and effective treatments for cocaine dependence. The researchers suggest that further investigation into cocaine-agonist medication strategies may be promising for certain subgroups of patients. This ongoing quest for knowledge and innovation is crucial for addressing the devastating impact of substance use disorders.

Dr.Camel's Conclusion

This study, like a reminder of the vast and unforgiving nature of the desert, underscores the complexities of treating cocaine dependence. While the journey to find effective treatments continues, the search for new approaches and the relentless pursuit of knowledge will lead us closer to a brighter future for those battling addiction.

Date :
  1. Date Completed 1996-07-11
  2. Date Revised 2019-09-14
Further Info :

Pubmed ID

8635177

DOI: Digital Object Identifier

10.1097/00002826-199504000-00009

Related Literature

Article Analysis
・Side Effects of diethylpropion
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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