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Systemic uptake of 5-aminosalicylic acid from olsalazine and eudragit L coated mesalazine in patients with ulcerative colitis in remission.

Author: BeckerK, EweK, UeberschaerB

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Aminosalicylates are used to maintain remission in ulcerative colitis, but they can have systemic side effects. This trial compared the efficacy and safety of olsalazine (Dipentum) and eudragit L coated mesalazine (Salofalk) in patients with ulcerative colitis. The study aimed to determine which preparation had lower rates of absorption in the small intestine, minimizing systemic side effects.
Paper Details　
Original Abstract of the Article :
Aminosalicylates are used to maintain remission in patients with ulcerative colitis. Since there are potential systemic side effects of 5-aminosalicylic acid (5-ASA) and long term treatment is necessary for maintenance therapy preparations with low rates of absorption in the small intestine would be...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8686349

データ提供：米国国立医学図書館（NLM）

Targeting the Gut: Systemic Absorption of 5-Aminosalicylic Acid

The field of [inflammatory bowel disease (IBD) research] constantly seeks better ways to manage [ulcerative colitis]. This study compares two medications containing [5-aminosalicylic acid (5-ASA)], [olsalazine (Dipentum)] and [eudragit L coated mesalazine (Salofalk)], in patients with [ulcerative colitis] in remission. The researchers aim to determine which medication provides the most targeted delivery of [5-ASA] to the colon, minimizing systemic side effects.

Precise Delivery

The findings suggest that both [olsalazine] and [eudragit L coated mesalazine] offer different approaches to delivering [5-ASA]. This information can help clinicians choose the most appropriate medication for individual patients, optimizing treatment outcomes.

Better Management for Ulcerative Colitis

This study contributes to the ongoing efforts to improve the management of [ulcerative colitis]. By understanding the systemic absorption of [5-ASA] from different medications, clinicians can personalize treatment plans and minimize potential side effects.

Dr. Camel's Conclusion

Just like a camel carefully stores water in its hump for long journeys, the efficient delivery of medication to the gut is crucial for managing [ulcerative colitis]. This research helps us understand how different medications can target this area for optimal treatment outcomes.

Date :
  1. Date Completed 1996-08-20
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8686349

DOI: Digital Object Identifier

8686349

Related Literature

Article Analysis
・Side Effects of olsalazine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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