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Dapsone toxicity: some current perspectives.

Author: ColemanM D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This article discusses the mechanisms of action and adverse effects of dapsone, an anti-inflammatory and anti-parasitic drug. Dapsone is metabolized to hydroxylamines, which can cause methaemoglobinaemia and haemolysis. However, erythrocytes can detoxify the hydroxylamine, contributing to dapsone's efficacy. The hydroxylamine metabolite can also lead to agranulocytosis, a potentially fatal side effect. The use of cimetidine, a metabolic inhibitor, can reduce the formation of the hydroxylamine and improve patient tolerance to dapsone.
Paper Details　
Original Abstract of the Article :
1. Dapsone is a potent anti-inflammatory and anti-parasitic compound, which is metabolised by cytochrome P-450 to hydroxylamines, which in turn cause methaemoglobinaemia and haemolysis. However, during the process of methaemoglobin formation, erythrocytes are capable of detoxifying the hydroxylamine...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://doi.org/10.1016/0306-3623(95)00029-1

データ提供：米国国立医学図書館（NLM）

Dapsone Toxicity: A Camel's Guide to Drug Safety in the Desert of Pharmacology

Dapsone, a medication used to treat various conditions, can sometimes cause adverse effects. This research delves into the mechanisms of dapsone toxicity, exploring the potential for drug interactions and developing strategies to minimize the risk of side effects. The study focuses on the role of cytochrome P-450 in dapsone metabolism and the potential for hydroxylamine metabolites to cause methaemoglobinaemia and haemolysis.

Navigating the Desert of Dapsone Therapy: Balancing Benefits and Risks

The study reveals the complex interplay of factors involved in dapsone toxicity. It's like navigating a challenging desert landscape, where careful planning and understanding of the terrain are crucial for a safe and successful journey. The research highlights the importance of minimizing the formation of hydroxylamine metabolites to reduce the risk of adverse effects.

Seeking a Safe Path: Finding Solutions in the Desert of Drug Safety

This research underscores the need for strategies to enhance patient tolerance to dapsone. The study proposes using a metabolic inhibitor, like a protective shield, to reduce the formation of harmful metabolites. This approach can help ensure a safer and more effective treatment experience for patients. It's like finding a hidden oasis in the desert of drug safety, offering a path towards safer and more effective treatment.

Dr.Camel's Conclusion

This research provides a valuable exploration of dapsone toxicity, offering insights into the mechanisms involved and potential strategies for minimizing adverse effects. By understanding these complexities, healthcare providers can optimize treatment plans and ensure the safe and effective use of dapsone for their patients. As we continue to explore the vast desert of pharmacology, we can strive to create a safer and more effective medication landscape for all.

Date :
  1. Date Completed 1996-08-27
  2. Date Revised 2019-08-26
Further Info :

Pubmed ID

8690232

DOI: Digital Object Identifier

10.1016/0306-3623(95)00029-1

Related Literature

Article Analysis
・Side Effects of cimetidine
SNS
PICO Info
in preparation
Languages

English

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