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Zolpidem, triazolam, and temazepam: behavioral and subject-rated effects in normal volunteers.

Author: GriffithsR R, RushC R

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study compared the effects of zolpidem, triazolam, and temazepam on learning, recall, and performance in 11 healthy volunteers. All three drugs produced dose- and time-dependent impairments in cognitive function, with zolpidem having a faster onset of action than the other two. Despite zolpidem's unique benzodiazepine receptor-binding profile, its behavioral and subjective effects were similar to those of triazolam and temazepam. This suggests that zolpidem's efficacy and safety profile may be similar to other benzodiazepines.
Paper Details　
Original Abstract of the Article :
Zolpidem is an imidazopyridine hypnotic that is biochemically distinct from classic benzodiazepine agonists in that it may be selective for the BZ1 receptor subtype and shows a different pattern of distribution of binding sites. The present study compared the learning, recall, performance, subject-r...See full text at original site
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引用元：
https://doi.org/10.1097/00004714-199604000-00007

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Sleep: A Comparative Study of Hypnotics

Sleep disturbances, like a scorching desert sun, can disrupt our daily lives. This study, like a camel seeking a restful haven in the vast desert of sleep research, compares the effects of zolpidem, triazolam, and temazepam, three common hypnotic medications. The researchers investigated the behavioral, subject-rated, and observer-rated effects of these drugs, providing valuable insights into their comparative properties.

Unveiling the Secrets of Sleep: A Comparative Analysis of Hypnotics

The study reveals that all three hypnotics, like different paths through the desert, produce similar effects on learning, recall, and performance, albeit with differing time courses. Zolpidem, like a shortcut through the desert, exhibits a faster onset of action than triazolam or temazepam. These findings highlight the importance of considering individual patient characteristics and the desired time course of hypnotic effects when choosing a medication.

Finding the Right Path to Sleep: Choosing the Best Hypnotic

This study, like a guide through the desert of sleep disorders, provides valuable information for healthcare professionals and individuals seeking to improve their sleep. It offers insights into the comparative effects of different hypnotics, allowing for more informed treatment decisions. The study emphasizes the importance of considering individual factors, such as the desired onset of action and potential side effects, when choosing a hypnotic medication.

Dr.Camel's Conclusion

This study, like a camel navigating the complex landscape of sleep research, provides valuable insights into the comparative effects of zolpidem, triazolam, and temazepam. It underscores the importance of careful consideration of individual patient needs and the desired time course of action when choosing a hypnotic medication, seeking the most effective path to restful sleep.

Date :
  1. Date Completed 1996-08-29
  2. Date Revised 2019-09-09
Further Info :

Pubmed ID

8690830

DOI: Digital Object Identifier

10.1097/00004714-199604000-00007

Related Literature

Article Analysis
・Effects of zolpidem・Effects of ulipristal
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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