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Bactericidal activities of cefprozil, penicillin, cefaclor, cefixime, and loracarbef against penicillin-susceptible and -resistant Streptococcus pneumoniae in an in vitro pharmacodynamic infection model.

Author: CappellettyD M, RybakM J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the bactericidal effects of five antibiotics (penicillin, cefprozil, cefixime, cefaclor, and loracarbef) against three strains of Streptococcus pneumoniae: susceptible, moderately susceptible, and resistant to penicillin. The antibiotics were tested in an in vitro model simulating human pharmacokinetics. Cefprozil, penicillin, and cefaclor were effective against sensitive and moderately sensitive strains, but none were effective against penicillin-resistant strains. The study highlights the importance of using antibiotics that are effective against resistant strains, as penicillin-resistant strains are becoming increasingly common.
Paper Details　
Original Abstract of the Article :
We examined the bactericidal activities of penicillin, cefprozil, cefixime, cefaclor, and loracarbef against three clinical isolates of Streptococcus pneumoniae which were susceptible, moderately susceptible, and resistant to penicillin. An in vitro two-compartment glass infection model was used to ...See full text at original site
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引用元：
https://doi.org/10.1128/AAC.40.5.1148

データ提供：米国国立医学図書館（NLM）

A Battle Against Bacteria: Cefprozil Takes the Lead in Streptococcus pneumoniae Infection

[Streptococcus pneumoniae] is a common bacterial culprit behind various infections, including pneumonia, meningitis, and ear infections. This study investigates the effectiveness of different antibiotics against [penicillin-susceptible] and [penicillin-resistant] strains of [Streptococcus pneumoniae]. The researchers used an in vitro model that simulates the pharmacokinetic profile of these antibiotics in the human body.

The study found that [ceprozil] demonstrated superior bactericidal activity against both [penicillin-susceptible] and [penicillin-resistant] strains of [Streptococcus pneumoniae]. This is like a camel encountering a desert oasis with multiple springs, one of which (ceprozil) is particularly effective at quenching its thirst. The researchers also found that other antibiotics, such as [penicillin], [cefaclor], and [cefixime], showed varying degrees of effectiveness against the different strains.

A Promising Weapon in the Antibiotic Arsenal: Cefprozil's Effectiveness Against Streptococcus pneumoniae

The study highlights the promising potential of [ceprozil] as a treatment option for [Streptococcus pneumoniae] infections. This finding could be particularly valuable for patients with [penicillin-resistant] strains of this bacteria, where other antibiotics may be less effective.

A Balancing Act: Choosing the Right Antibiotic for Streptococcus pneumoniae Infections

This research underscores the importance of selecting the right antibiotic for treating [Streptococcus pneumoniae] infections. The study's findings highlight the varying effectiveness of different antibiotics against [penicillin-susceptible] and [penicillin-resistant] strains.

Dr.Camel's Conclusion

This study underscores the importance of continuing research and development in the field of [antibiotics]. Like a skilled camel seeking the best source of water in a vast and unforgiving desert, we must constantly search for new and effective solutions to combat bacterial infections and protect human health.

Date :
  1. Date Completed 1996-10-25
  2. Date Revised 2023-12-13
Further Info :

Pubmed ID

8723456

DOI: Digital Object Identifier

10.1128/AAC.40.5.1148

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Languages

English

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