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Effect of naftifine on neutrophil adhesion.

Author: ChoiT S, FikrigS, GeenS, LeeW L, NowakowskiM, ShalitaA R, SolomonB, SuntharalingamK

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The study investigated the in vitro effect of naftifine (NF), a topical antifungal agent, on polymorphonuclear leukocyte (PMN) adherence to endothelia. NF significantly reduced PMN adherence to various substrates, including endothelial monolayers. This inhibition may contribute to the anti-inflammatory effect of NF.
Paper Details　
Original Abstract of the Article :
Effective methods of fungal treatment involve reduction in fungal infections and host inflammatory responses. Naftifine (NF), a topical antifungal agent, is highly active in vitro and in vivo against a wide range of pathogenic fungi. Additionally NF has been shown to inhibit polymorphonuclear leukoc...See full text at original site
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引用元：
https://doi.org/10.1159/000211415

データ提供：米国国立医学図書館（NLM）

Naftifine: A Multifaceted Antifungal Agent With Anti-Inflammatory Potential

Fungal infections can be a real nuisance, causing a variety of skin problems. Naftifine (NF), a topical antifungal agent, is known for its effectiveness against various fungal pathogens. This study explored the potential anti-inflammatory properties of NF, investigating its effects on neutrophil adhesion, a key process in the inflammatory response.

Naftifine Inhibits Neutrophil Adhesion: A Potential Anti-Inflammatory Mechanism

The study found that NF significantly inhibited neutrophil adhesion to various surfaces, including nylon fiber, BSA-coated glass chambers, polystyrene, and endothelial monolayers. This finding suggests that NF may exert its anti-inflammatory effects, at least partially, by inhibiting neutrophil adhesion, a critical step in the recruitment of inflammatory cells to the site of infection. It's like NF is building a sandcastle barrier in the desert of inflammation, preventing the inflammatory cells from reaching their target.

A Multifaceted Approach to Fungal Infections

This research reveals the multifaceted nature of NF, highlighting its potential as an anti-inflammatory agent in addition to its antifungal properties. This suggests that NF might be a valuable tool in managing fungal infections and minimizing the associated inflammatory response.

Dr. Camel's Conclusion

This study uncovers a hidden oasis of anti-inflammatory potential within the desert of antifungal agents, suggesting that naftifine might offer a two-pronged approach to managing fungal infections.

Date :
  1. Date Completed 1996-11-05
  2. Date Revised 2019-11-01
Further Info :

Pubmed ID

8737916

DOI: Digital Object Identifier

10.1159/000211415

Related Literature

Article Analysis
・Effects of naftifine topical
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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