Effects of naftifine topical: A Synthesis of Findings from 32 Studies

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Original Abstract of the Article

Major findings

Naftifine is a topical antifungal medication that has been shown to be effective in treating various fungal skin infections, including athlete's foot, jock itch, and tinea versicolor. 13 , 18 , 21 , 19 , 9 , 15 , 6 , 20 Naftifine works by inhibiting the growth of fungi by interfering with the formation of fungal cell membranes. 26 , 32 , 30 , 29 , 27 , 7 , 16 Studies have shown that naftifine can be effective even when used in combination with other antifungal medications, such as terbinafine and ketoconazole. 10 In addition, naftifine has been shown to be effective against a wide range of dermatophytes, including Trichophyton rubrum, T. mentagrophytes, T. tonsurans, Epidermophyton floccosum, and Microsporum canis. 16 Furthermore, naftifine has been found to have anti-inflammatory effects, potentially aiding in reducing skin irritation and redness. 15 , 6 While the effectiveness of naftifine is promising, it is important to note that there is still a limited amount of research on its use in children, especially regarding optimal dosage and long-term effects. 9 , 6

Benefits and Risks

Benefits Summary

Naftifine is a safe and effective topical treatment for a range of fungal skin infections. It has been shown to effectively clear infections, and its anti-inflammatory properties can help to reduce skin irritation and redness. Its overall safety profile is good, with few reported side effects.

Risks Summary

Naftifine can cause skin irritation, but this is relatively uncommon and typically mild. More research is needed to fully assess its long-term effects, especially in children. It is important to always consult with a doctor before using any medication, including topical antifungals.

Comparison Across Studies

Commonalities

Most studies have demonstrated that naftifine is effective in treating fungal skin infections, and it is generally well-tolerated. It has been shown to be effective against a wide range of dermatophytes, and it can be used alone or in combination with other antifungal medications.

Differences

Studies vary in their methodology, participant demographics, and the specific fungal infections investigated. The specific formulations of naftifine used in the studies may also vary, potentially affecting the results. These differences can explain variations in the observed effectiveness and side effect profiles reported.

Consistency and Discrepancies

Although there is a general consistency in the findings that naftifine is an effective topical antifungal, the specific effectiveness and side effects observed can vary. Further research is needed to better understand the nuances of its efficacy and safety in different patient populations and with different types of fungal infections.

Practical Application and Considerations

Naftifine can be a valuable tool for treating fungal skin infections, but it is essential to follow a doctor's instructions carefully. Always use the medication as prescribed, and if you experience any unusual side effects or if your symptoms worsen, contact your doctor immediately.

Limitations of Current Research

The available research on naftifine is somewhat limited, especially regarding its long-term effects, its use in children, and its effectiveness against specific fungal strains. More robust and comprehensive studies are needed to better understand these aspects of naftifine's use.

Future Research Directions

Future research should focus on addressing the current limitations. Specifically, further research is needed to:
1. Evaluate the long-term safety and effectiveness of naftifine, especially in children.
2. Examine the effectiveness of naftifine against different strains of fungi, including those that are becoming resistant to other antifungal medications.
3. Investigate the optimal dosage and application methods of naftifine for various fungal infections and patient demographics.
4. Further explore the anti-inflammatory properties of naftifine and its potential benefits in reducing skin irritation and inflammation.

Conclusion

Naftifine is a promising topical antifungal medication that can effectively treat a range of fungal skin infections. While generally well-tolerated, it is essential to use naftifine as prescribed and to monitor for potential side effects. More research is needed to fully understand its long-term effects and optimal usage in diverse patient populations. If you experience a fungal skin infection, consult with a doctor to discuss the most appropriate treatment options, including whether naftifine might be suitable for your individual case.

Literature analysis of 32 papers
Positive Content
32
Neutral Content
0
Negative Content
0
Article Type
3
5
6
15
32
1.

Unintended events following immunization with MMR: a systematic review.

Author: JeffersonTom, PriceDeirdre, DemicheliVittorio, BiancoElvira,

Lower respiratory infections
MMR vaccine effectiveness
Aseptic meningitis
Irritability
Joint pain
Parotitis
Thrombocytopenic purpura

A systematic review of 22 studies found that the MMR vaccine is associated with a lower incidence of upper respiratory tract infections, a higher incidence of irritability, and similar incidence of other adverse effects compared to placebo. It is likely associated with benign thrombocytopenic purpura (TP), parotitis, joint and limb complaints, and aseptic meningitis (mumps Urabe strain-containing MMR). Exposure to MMR is unlikely to be associated with Crohn's disease, ulcerative colitis, autism, or aseptic meningitis (mumps Jeryl-Lynn strain-containing MMR).

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

2.

Non-specific effects of MMR vaccines on infectious disease related hospitalizations during the second year of life in high-income countries: a systematic review and meta-analysis.

Author: SinzingerAndrea Xaver, Von KriesRüdiger, SiedlerAnette, WichmannOle, HarderThomas

MMR vaccination
confounding factors
vaccine bias

This study reviewed the evidence regarding the potential benefit of MMR vaccination on the risk of hospitalization due to infectious diseases. The available evidence is insufficient to support a change in current vaccination schedules.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

5.

Topical antiviral and antifungal medications in pregnancy: a review of safety profiles.

Author: PatelV M, SchwartzR A, LambertW C

Topical antifungal safety
Topical antiviral safety

This article aggregates human and animal studies to provide recommendations on utilizing topical antiviral and antifungal medications in pregnancy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Efficacy and Safety of Naftifine HCl Cream 2% in the Treatment of Pediatric Subjects With Tinea Corporis.

Author: GoldMichael, DhawanSunil, VermaAmit, KuligowskiMichael, DobrowskiDavid

Tinea corporis treatment

Naftifine hydrochloride is a topical antifungal of the allylamine class used to treat tinea corporis, displaying fungicidal activity and clinically significant anti-bacterial and anti-inflammatory effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

[In vitro Antifungal Activity of Luliconazole against Trichophyton spp].

Author: MaedaJun, NanjohYasuko, KogaHiroyasu, TogaTetsuo, MakimuraKoichi, TsuboiRyoji

Dermatophytosis treatment

This study compared the antifungal activity of luliconazole to that of six other commonly used topical antifungal drugs against Trichophyton rubrum and Trichophyton mentagrophytes, the two most common causes of tinea. Luliconazole was found to be the most potent antifungal drug tested.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Japanese

8.

New Topical Therapeutic Options in the Management of Superficial Fungal Infections.

Author: ZeichnerJoshua A

Topical treatment

Dermatophyte infections of the skin and nails are common in the United States. Newer topical drugs, such as luliconazole, naftifine, efinaconazole, and tavaborole, are effective and safe treatments for these infections.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

An Open-Label, Multi-Center, Multiple-Application Pharmacokinetic Study of Naftifine HCl Gel 2% in Pediatric Subjects With Tinea Pedis.

Author: VermaAmit, OlayinkaBabajide, FleischerAlan B

Tinea pedis treatment

Naftifine hydrochloride is a topical antifungal used to treat tinea pedis. This study reviewed clinical data on the use of naftifine for tinea pedis in a pediatric population.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

10.

Generalized superficial mycosis caused by Trichophyton raubitschekii in China: case report and review of the literature.

Author: ZhangHao, XiongXincai, LiuTing, RanYuping

Superficial mycosis treatment

This case study describes a generalized superficial mycosis case from which Trichophyton raubitschekii was isolated.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Evidence-based topical treatments for tinea cruris and tinea corporis: a summary of a Cochrane systematic review.

Author: van ZuurenE J, FedorowiczZ, El-GoharyM

Tinea treatment

This review assessed the evidence for topical treatments of tinea cruris and tinea corporis. Terbinafine showed a statistically significant higher clinical cure rate compared to placebo, while naftifine showed a similar result but with lower evidence quality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

Topical antifungal treatments for tinea cruris and tinea corporis.

Author: El-GoharyMagdy, van ZuurenEsther J, FedorowiczZbys, BurgessHana, DoneyLiz, StuartBeth, MooreMichael, LittlePaul

Tinea treatment

Tinea infections are fungal skin infections that affect 10-20% of the world's population. Types of tinea infections and their locations vary. Tinea corporis (ringworm) and tinea cruris (jock itch) are common. Diagnosis is based on appearance and can be confirmed with tests. Many topical antifungal medications are used, but the most effective options are not clear.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

13.

What is new in fungal pharmacotherapeutics?

Author: RouttEthan T, JimShelbi C, ZeichnerJoshua A, KircikLeon H

Onychomycosis treatment
Tinea pedis treatment

This article reviews new and emerging pharmacotherapeutics for onychomycosis and tinea pedis. Advancements in formulation technology have led to more effective and safer treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

15.

Efficacy and safety of naftifine HCl Gel 2% in the treatment of interdigital and moccasin type tinea pedis: pooled results from two multicenter, randomized, double-blind, vehicle-controlled trials.

Author: Stein GoldLinda F, ParishLawrence Charles, VlahovicTracey, PlaumStefan, KircikLeon, FleischerAlan B, VermaAmit, OlayinkaBabajide, HardasBhushan

Effective tinea pedis treatment
Minimal side effects

This study evaluated the efficacy and safety of two-weeks once daily application of naftifine gel 2% for treating tinea pedis. Naftifine gel 2% was well-tolerated and effective in treating both interdigital-type and moccasin-type tinea pedis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

17.

Efficacy of topical antifungals in the treatment of dermatophytosis: a mixed-treatment comparison meta-analysis involving 14 treatments.

Author: RottaInajara, ZiegelmannPatricia K, OtukiMichel F, RiverosBruno S, BernardoNoemia L M C, CorrerCassyano J

Improved antifungal treatment

This mixed-treatment comparison meta-analysis examined the evidence for antifungal treatments, showing all available evidence at the time of the study.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

An open-label pilot study of naftifine 1% gel in the treatment of seborrheic dermatitis of the scalp.

Author: GoldMichael H, BridgesTancy, AvakianEdward V, PlaumStefan, FleischerAlan B, HardasBhushan

Seborrheic dermatitis treatment

Naftifine 1% gel, a topical antifungal, was found to be safe and effective in treating moderate seborrheic dermatitis (SD) of the scalp in a small study of 9 patients. After 4 weeks of treatment, there was a significant improvement in SD symptoms, including a 66% decrease in the SD Global Evaluation Scale (SDGES) score and a 54% decrease in scalp involvement. Additionally, erythema and scaling decreased by 38% and 50% respectively.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

An open-label study of naftifine hydrochloride 1% gel in the treatment of tinea versicolor.

Author: GoldMichael H, BridgesTancy, AvakianEdward, PlaumStefan, PappertEric J, FleischerAlan B, HardasBhushan

Safe treatment
Tinea versicolor treatment

Naftifine 1% gel, applied twice daily for 2 weeks, was found to be a safe and efficacious topical treatment for tinea versicolor in a pilot study of 10 patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

20.

A randomized, double-blind, vehicle-controlled efficacy and safety study of naftifine 2% cream in the treatment of tinea pedis.

Author: ParishLawrence Charles, ParishJennifer L, RouthHirak B, FleischerAlan B, AvakianEdward V, PlaumStefan, HardasBhushan

Tinea pedis treatment efficacy

Naftifine HCl 2% cream is a topical antifungal treatment for tinea pedis. This study showed that NAFT-2 is effective and safe for two weeks of treatment.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

A double-blind, randomized, vehicle-controlled study evaluating the efficacy and safety of naftifine 2% cream in tinea cruris.

Author: ParishLawrence Charles, ParishJennifer L, RouthHirak B, AvakianEdward, OlayinkaBabajide, PappertEric J, PlaumStefan, FleischerAlan B, HardasBhushan

effective for Tinea cruris
safe

This study evaluated the efficacy and safety of naftifine HCl 2% cream in the treatment of tinea cruris, a fungal infection. The study found that naftifine HCl 2% cream was effective in treating tinea cruris and was well tolerated.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Athlete's foot.

Author: CrawfordFay

Reduced athlete's foot

Topical allylamines (naftifine and terbinafine), topical azoles (bifonazole, clotrimazole, econazole nitrate, miconazole nitrate, sulconazole nitrate, and tioconazole), and topical ciclopirox olamine are effective treatments for athlete's foot.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

Athlete's foot.

Author: CrawfordFay

Improved foot hygiene
Treats athlete's foot

This systematic review provides information on the effectiveness and safety of various topical treatments for athlete's foot, including improved foot hygiene, topical allylamines, topical azoles, and topical ciclopirox olamine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

24.

[Antimycotic therapy of Tinea pedis and other foot mycoses].

Author: StockIngo

Systemic treatment
Topical treatment

This article reviewed fungal foot infections, their causes, symptoms, and treatment options.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

26.

Butenafine hydrochloride: for the treatment of interdigital tinea pedis.

Author: SyedT A, MaibachH I

Tinea pedis treatment
Burning sensation

Butenafine, a new generation of antimycotic compound, is effective against tinea pedis. It has a potent fungicidal activity and is well tolerated with minimal side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

27.

Terbinafine. An update of its use in superficial mycoses.

Author: McClellanK J, WisemanL R, MarkhamA

Effective for dermatophyte infections
Well-tolerated

Oral terbinafine is effective in the treatment of superficial dermatophyte infections such as onychomycosis, tinea pedis, and tinea corporis/cruris.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

28.

Comparative study of the in vitro antifungal activity of bifonazole, naftifine and sertaconazole against yeasts.

Author: Carrillo-MuñozA J, Tur-TurC, Bornay-LlinaresF J, ArévaloP

Sertaconazole was found to be more active against Candida spp than other topical antifungal agents such as bifonazole and naftifine.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

29.

Butenafine.

Author: McNeelyW, SpencerC M

Fungicidal activity
Mycological cure
Overall cure

Butenafine, a new antifungal agent with primary fungicidal activity against dermatophytes, was found to have greater activity against T. rubrum, M. gypseum and Epidermophyton floccosum when compared with naftifine, tolnaftate, and clotrimazole.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

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