Paper Details

  1. Home
  2. Paper Details

Mutagenic damage to mammalian cells by therapeutic alkylating agents.

Author: SandersonB J, ShieldA J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Alkylating agents, used as cancer therapeutics, can cause cell death by reacting with DNA, RNA, and proteins. These agents can also induce mutations and secondary malignancies, and their mutagenic potential may be increased after metabolic activation.
Paper Details　
Original Abstract of the Article :
Cytotoxic alkylating agents used as therapeutics include nitrogen mustards, ethyleneimines, alkyl sulfonates, nitrosoureas and triazenes. Their reactivity with DNA, RNA and proteins can cause cell death. Side-effects of treatment include tissue toxicity and secondary malignancies, likely due to the ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0027-5107(96)00021-8

データ提供：米国国立医学図書館（NLM）

The Mutagenic Footprint of Alkylating Agents: Navigating the Desert of DNA Damage

Alkylating agents, used in cancer chemotherapy, are like desert winds, capable of causing significant damage to DNA, RNA, and proteins. This study explores the mutagenic potential of these agents, highlighting the complex interplay between their reactivity, metabolic activation, and the resulting mutations. It's like deciphering the cryptic messages left behind by a sandstorm, understanding the intricate patterns of damage caused by these potent chemicals.

Unraveling the Damage: Mapping the Mutagenic Landscape

The study reveals that alkylating agents can induce a variety of mutations, including base substitutions and crosslinks, leading to cellular death and potential secondary malignancies. It's like tracing the paths of a sandstorm, identifying the areas most heavily affected by its destructive force.

Minimizing the Risk: Protecting Against the Desert's Fury

This research provides crucial insights into the mutagenic potential of alkylating agents, highlighting the importance of understanding their mechanisms of action and developing strategies to minimize their side effects. It's like developing protective measures against a desert sandstorm, ensuring that the traveler's journey is safe and successful.

Dr. Camel's Conclusion

This study highlights the complex mutagenic potential of alkylating agents, emphasizing the importance of understanding their mechanisms of action and developing strategies to minimize their side effects. It's a reminder that even in the most effective treatments, there are inherent risks that must be carefully considered and managed.

Date :
  1. Date Completed 1996-10-10
  2. Date Revised 2019-07-02
Further Info :

Pubmed ID

8781576

DOI: Digital Object Identifier

10.1016/0027-5107(96)00021-8

Related Literature

Article Analysis
・Side Effects of mechlorethamine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.