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Pathology of androgen deprivation therapy in prostate carcinoma. A comparative study of 173 patients.

Author: BanksE R, CivantosF, DrewP A, HoC K, MarcialM A, MurphyW M, SolowayM S, SpeightsV O

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the pathologic changes in the prostate induced by androgen deprivation therapy using leuprolide and flutamide in two small series of patients with clinically localized prostate cancer. The findings revealed discrepancies in the presence of squamous metaplasia, necrosis, and possible tumor destruction.
Paper Details　
Original Abstract of the Article :
Leuprolide, an agonist of luteinizing hormone-releasing hormone (LH-RH), and flutamide, an antiandrogen, increasingly are being used in the treatment of clinically localized prostate cancer. Only two small series (of 23 and 12 patients) have been published on the distinctive pathologic changes induc...See full text at original site
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引用元：
https://doi.org/10.1002/1097-0142(19950401)75:7<1634::aid-cncr2820750713>3.0.co;2-#

データ提供：米国国立医学図書館（NLM）

Androgen Deprivation Therapy: A Shifting Landscape in Prostate Cancer Treatment

Prostate cancer, like a relentless sandstorm, can wreak havoc on the body. This study delves into the impact of androgen deprivation therapy (ADT) on prostate cancer, examining the distinctive pathological changes induced by two commonly used therapies, leuprolide and flutamide. The authors conducted a comparative study involving 173 patients, exploring the effects of these therapies on prostate tissue. They observed a range of changes, including squamous metaplasia, necrosis, and potential tumor destruction. The study highlights the complex interplay between ADT and prostate cancer, emphasizing the need for a deeper understanding of the pathological changes associated with these therapies. The authors suggest that combined androgen deprivation therapy may play a role in tumor destruction, but further research is needed to fully understand its impact.

Androgen Deprivation Therapy: A Shifting Landscape in Prostate Cancer Treatment

This research provides valuable insights into the complex landscape of prostate cancer treatment, highlighting the potential benefits and challenges associated with androgen deprivation therapy. The study underscores the need for a thorough understanding of the pathological changes induced by these therapies to optimize treatment strategies and improve outcomes for patients. It's like navigating a desert with a changing landscape, requiring constant vigilance and careful planning to ensure success.

Living with Prostate Cancer: Navigating the Desert with Knowledge and Care

This research emphasizes the importance of informed and individualized care for patients with prostate cancer. The study's findings highlight the complex interplay between androgen deprivation therapy and prostate cancer, underscoring the need for careful monitoring and a deep understanding of the potential benefits and risks. By approaching prostate cancer treatment with a collaborative and informed perspective, we can help patients navigate the challenging terrain of this disease with greater confidence and hope.

Dr.Camel's Conclusion

This research explores the complex effects of androgen deprivation therapy on prostate cancer. Understanding the potential benefits and challenges of this therapy is crucial for optimizing treatment strategies and improving outcomes for patients. As we continue to explore the desert of prostate cancer research, we must remain vigilant in our search for more effective and personalized approaches to this challenging disease.

Date :
  1. Date Completed 1996-11-06
  2. Date Revised 2019-06-20
Further Info :

Pubmed ID

8826921

DOI: Digital Object Identifier

10.1002/1097-0142(19950401)75:7<1634::aid-cncr2820750713>3.0.co;2-#

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Article Analysis
・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

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