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Paper Details

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Paper Details

Early institution of bromocriptine in Parkinson's disease inhibits the emergence of levodopa-associated motor side effects. Long-term results of the PRADO study.

Author: BlümnerE, DanielczykW, GerlachM, KaiserH J, KrausP H, LetzelH, PrzuntekH, RiedererP, UberlaK, WelzelD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Partial substitution of levodopa with bromocriptine (>30%) as first-line treatment of Parkinson's disease reduced the risk of levodopa-associated motor side effects by one third.

Paper Details　

Original Abstract of the Article :

Long-term levodopa treatment in Parkinson's disease is typically associated with "motor side effects" consisting in dyskinesias and/or fluctuations in motility referred to as the on-off phenomena. The main objective of this prospective, randomized, multi-centre study was to determine to what extent ...See full text at original site

Dr.Camel's Paper Summary Blog

in preparation

Date :

Date Completed 1996-12-17
Date Revised 2018-11-13

Further Info :

Pubmed ID

DOI: Digital Object Identifier

10.1007/BF01271230

Related Literature

Article Analysis

・Side Effects of bromocriptine

SNS

PICO Info

in preparation

Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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