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Extrapyramidal side effects in chlorpromazine recipients: emergence according to benztropine prophylaxis.

Author: ColeJ O, ShapiroS, SloneD, SwettC

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

The frequency of extrapyramidal symptoms (EPS) attributed to chlorpromazine was compared in 86 patients receiving benztropine for EPS prevention and 568 patients receiving chlorpromazine alone. The study found no significant difference in the rate of EPS between the two groups, suggesting that prophylactic use of benztropine does not reduce the rate of EPS.
Paper Details　
Original Abstract of the Article :
The frequency of extrapyramidal symptoms (EPS) attributed to chlorpromazine among 86 patients who received benztropine for the prevention of EPS (9.3%) was similar to that of the 568 patients who received chlorpromazine alone (10.6%). The data in this small sample indicated that the prophylactic use...See full text at original site
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引用元：
https://doi.org/10.1001/archpsyc.1977.01770200080009

データ提供：米国国立医学図書館（NLM）

Extrapyramidal Side Effects: A Delicate Balance in Medication

The use of antipsychotic medications, such as chlorpromazine, can sometimes lead to unwanted side effects, known as extrapyramidal symptoms (EPS). Think of it like a camel caravan encountering a sandstorm, causing disruptions and potential damage. This research investigates the effectiveness of a preventative medication, benztropine, in reducing the incidence of EPS in patients taking chlorpromazine. The study aims to determine whether benztropine can effectively mitigate these side effects, improving the overall treatment experience for patients.

Benztropine: A Shield Against Side Effects

The study found that the use of benztropine as a prophylaxis did not significantly reduce the incidence of EPS in patients taking chlorpromazine. It’s like a camel caravan encountering a sandstorm, even with a protective shield, the impact can still be felt. The research highlights the need for further investigation into more effective ways to prevent or manage EPS, particularly in patients taking chlorpromazine.

Navigating the Side Effects of Medication

This research emphasizes the importance of careful monitoring and personalized treatment approaches in managing the potential side effects of medications. It’s like navigating a desert, being aware of potential hazards and taking necessary precautions to ensure a safe journey. The study underscores the need for continued research to find ways to minimize EPS and improve the overall treatment experience for patients.

Dr.Camel's Conclusion

Managing the side effects of medication can be a delicate balancing act. This research reminds us that even with preventative measures, there may still be challenges along the way. We must continue to search for more effective strategies to minimize side effects and improve the overall well-being of our patients.

Date :
  1. Date Completed 1977-09-29
  2. Date Revised 2019-07-17
Further Info :

Pubmed ID

889418

DOI: Digital Object Identifier

10.1001/archpsyc.1977.01770200080009

SNS
PICO Info
in preparation
Languages

English

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