Paper Details

  1. Home
  2. Paper Details

Different effects of chronic administration of haloperidol and pimozide on dopamine metabolism in the rat brain.

Author: Antkiewicz-MichalukL, KarolewiczB, MichalukJ, VetulaniJ

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Haloperidol and pimozide had similar effects on dopamine metabolism after a single dose, but differed after chronic administration. Haloperidol produced hypersensitivity of the dopaminergic system, while pimozide did not.
Paper Details　
Original Abstract of the Article :
We investigated the differences between the action of haloperidol and pimozide on dopamine metabolism and on catalepsy in periods up to 6 weeks after cessation of chronic administration of the neuroleptics to male Wistar rats. Dopamine and its metabolites (dihydroxyphenylacetic and homovanillic acid...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/0014-2999(96)00451-7

データ提供：米国国立医学図書館（NLM）

Different effects of chronic administration of haloperidol and pimozide on dopamine metabolism in the rat brain

This research delves into the fascinating realm of neurochemistry, exploring the intricate interactions between neuroleptic drugs and the brain's dopamine system. Imagine it like a camel caravan navigating a desert of interconnected pathways, each route leading to a different destination. The authors compared the effects of two neuroleptic drugs, haloperidol and pimozide, on dopamine metabolism in rats, finding that haloperidol produced a more pronounced and sustained effect, potentially leading to a heightened sensitivity of the dopamine system.

A journey through the neural desert

This study offers a glimpse into the complex interplay between neuroleptic drugs and the brain's dopamine system. It's like following a camel caravan through a desert of neural pathways, observing the different effects of each drug on the brain's intricate landscape. The authors' findings provide valuable insights into the long-term effects of these drugs, highlighting the importance of considering their potential impact on the delicate balance of neurotransmitter systems.

Navigating the terrain of mental health

Understanding the effects of neuroleptic drugs on the brain is crucial for effective mental health care. This research underscores the need for individualized treatment plans and careful monitoring, allowing healthcare professionals to navigate the complex terrain of mental health with precision and compassion.

Dr. Camel's Conclusion

This study highlights the need for further research to understand the intricate workings of the brain and the impact of neuroleptic drugs on its delicate balance. It's a reminder that the desert of neurochemistry is vast and complex, with many secrets yet to be uncovered. By continuing to explore this terrain, we can develop more effective and personalized treatments for those seeking relief from mental health challenges.
Date :
  1. Date Completed 1997-03-07
  2. Date Revised 2019-06-24
Further Info :

Pubmed ID

8911913

DOI: Digital Object Identifier

10.1016/0014-2999(96)00451-7

Related Literature

Article Analysis
・Effects of pimozide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.