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The effects of cyproheptadine on vacuous jaw movements in rats: a comparison with haloperidol and clozapine.

Author: HarringtonA, KaczmarekH J, SteinpreisR E

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cyproheptadine produced vacuous jaw movements in rats, similar to those produced by haloperidol. This suggests that cyproheptadine may be similar to classic antipsychotics in the production of extrapyramidal symptoms in humans.
Paper Details　
Original Abstract of the Article :
Classic neuroleptics produce a syndrome of vacuous jaw movements in rats, but atypical neuroleptics such as clozapine do not. This syndrome has been offered as a rapid and inexpensive means of assaying novel antipsychotic compounds for the production of early onset extrapyramidal side effects. Cypro...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/8927662

データ提供：米国国立医学図書館（NLM）

Cyproheptadine: A New Player in the Game of Schizophrenia?

Schizophrenia, a complex mental disorder, is often treated with antipsychotic medications. However, these medications can have significant side effects, including extrapyramidal symptoms. This study explores the effects of cyproheptadine, a serotonergic antagonist, on vacuous jaw movements in rats, a model of extrapyramidal side effects.

The Desert of Extrapyramidal Symptoms: Exploring the Effects of Cyproheptadine

The study found that cyproheptadine, like the classic antipsychotic haloperidol, produced elevations in vacuous jaw movements, suggesting that it might be associated with extrapyramidal side effects in humans. This finding highlights the importance of carefully evaluating the potential side effects of new medications, especially those used for mental health conditions. It's like exploring a desert landscape, carefully mapping out the potential risks and hazards before embarking on a journey.

Navigating the Desert of Mental Health: A Search for Safer Treatments

The research underscores the need for ongoing investigation into the potential side effects of medications used to treat schizophrenia. It highlights the importance of finding new and safer treatment options for this complex condition, minimizing the risk of side effects while maximizing therapeutic efficacy. It's a reminder that the quest for better mental health treatments is an ongoing journey through a complex and challenging desert.

Dr.Camel's Conclusion

The search for effective and safe treatments for schizophrenia is a journey through a challenging desert. This study explores the potential of cyproheptadine, a serotonergic antagonist, as a treatment option. The findings raise concerns about potential extrapyramidal side effects, emphasizing the importance of continued research and development of new and safer therapeutic approaches for this complex condition. It's a reminder that the quest for better mental health treatments is an ongoing journey, and we must continue to explore new pathways and innovations to improve the lives of those affected.
Date :
  1. Date Completed 1996-11-27
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8927662

DOI: Digital Object Identifier

8927662

Related Literature

Article Analysis
・Effects of cyproheptadine
SNS
PICO Info
in preparation
Languages

English

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