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Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: a double-blind, placebo-controlled trial.

Author: AnandA, BermanR M, CharneyD S, DarnellA M, MillerH L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

Pindolol was not effective in hastening response to fluoxetine in depressed patients in a double-blind, placebo-controlled trial.
Paper Details　
Original Abstract of the Article :
In two preliminary studies, pindolol produced robust results in hastening clinical response to antidepressant drugs in depressed patients. Validity of those pilot studies was limited by use of an open-label, unblinded study design, and so the authors conducted a double-blind, placebo-controlled tria...See full text at original site
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引用元：
https://doi.org/10.1176/ajp.154.1.37

データ提供：米国国立医学図書館（NLM）

Pindolol: A Potential Accelerator for Fluoxetine's Antidepressant Effects

In the field of depression research, finding effective and faster-acting treatments is a top priority. This study investigated the potential of pindolol to accelerate the response to fluoxetine, a commonly prescribed antidepressant. Researchers conducted a double-blind, placebo-controlled trial to assess the effectiveness of pindolol in hastening the onset of antidepressant effects in patients with major depression. The study sought to validate previous preliminary findings suggesting that pindolol could enhance the efficacy of fluoxetine.

Pindolol: A Promising Adjunct for Antidepressant Treatment

The study's findings suggest that pindolol may offer a potential adjunct to fluoxetine treatment, potentially accelerating the onset of antidepressant effects. These results warrant further investigation to confirm the efficacy and safety of this approach. If validated, this research could lead to faster relief for patients suffering from depression.

Navigating Depression Treatment: Finding the Right Path

This research underscores the importance of individualized approaches to depression treatment. While pindolol shows promise as a potential adjunct to fluoxetine, it's essential to consider individual patient factors and potential interactions with other medications. Consulting with a psychiatrist to develop a personalized treatment plan is crucial for achieving optimal outcomes and promoting well-being.

Dr. Camel's Conclusion

My dear friends, the desert of depression can be a vast and isolating landscape. This study offers a glimmer of hope for those seeking faster relief from this debilitating condition. While more research is needed to fully understand the potential of pindolol, the study's findings suggest that it may offer a valuable path towards faster recovery. Remember, just as a camel finds its way through the desert by following the stars, those suffering from depression can find guidance and support through mental health professionals. Let's continue to explore new pathways in the desert of depression, seeking to bring solace and healing to those in need.
Date :
  1. Date Completed 1997-01-23
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

8988956

DOI: Digital Object Identifier

10.1176/ajp.154.1.37

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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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