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Long-term effects of tetrabenazine in hyperkinetic movement disorders.

Author: BeachJ, JankovicJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study found that tetrabenazine (TBZ) was effective and safe for treating a variety of hyperkinetic movement disorders, with marked improvement in over 80% of patients. The most common side effects, including drowsiness and parkinsonism, were manageable with dose reduction.
Paper Details　
Original Abstract of the Article :
Over the past 15 years we have treated 526 patients with severe hyperkinetic movement disorders with tetrabenazine (TBZ), a monoamine-depleting and a dopamine-receptor-blocking drug. We report here the results in 400 patients with adequate follow-up. The response was rated on a scale of 1 to 5 (1 = ...See full text at original site
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引用元：
https://doi.org/10.1212/wnl.48.2.358

データ提供：米国国立医学図書館（NLM）

Tetrabenazine: A Reliable Oasis in the Desert of Hyperkinetic Movement Disorders

Hyperkinetic movement disorders, such as Tourette’s syndrome, Huntington’s disease, and dystonia, are like an endless desert storm, causing involuntary movements and disrupting daily life. Researchers are continually searching for effective treatments that can calm these storms. This study explores the long-term effects of tetrabenazine, a medication that helps to reduce involuntary movements, in patients with hyperkinetic movement disorders.

Tetrabenazine: A Beacon of Hope in the Desert of Involuntary Movements

The study revealed that tetrabenazine was effective in reducing involuntary movements in a wide range of patients, with significant improvement reported for conditions such as tardive stereotypy, myoclonus, Huntington’s disease, tardive dystonia, and Tourette’s syndrome. This finding offers a beacon of hope in the desert of hyperkinetic movement disorders, providing individuals with the potential to regain control of their movements and live more fulfilling lives.

Navigating the Landscape of Treatment

While tetrabenazine is generally well-tolerated, it’s important to be aware of potential side effects like drowsiness, parkinsonism, and depression. These side effects can be managed by adjusting the dosage, emphasizing the importance of close monitoring and communication with your healthcare provider. This research highlights the importance of finding the right treatment and dose for each individual, ensuring a smooth journey through the desert of hyperkinetic movement disorders.

Dr.Camel's Conclusion

This study demonstrates the effectiveness of tetrabenazine in managing hyperkinetic movement disorders, offering a much-needed oasis in the desert of involuntary movements. The research underscores the importance of personalized medicine and careful monitoring to ensure optimal treatment and minimize potential side effects. With tetrabenazine, individuals with hyperkinetic movement disorders can navigate the challenging terrain of their condition with greater control and improved quality of life.

Date :
  1. Date Completed 1997-03-26
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

9040721

DOI: Digital Object Identifier

10.1212/wnl.48.2.358

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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