Paper Details 
Original Abstract of the Article :
The pharmacodynamic and toxicological profile of the new angiotensin converting enzyme (ACE) inhibitor moexipril (CAS 82586-52-5) and its active diacid metabolite moexiprilat were studied in vitro as well as in vivo. In vitro, moexiprilat was a potent inhibitor of ACE in guinea pig serum as well as ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/9079232

データ提供:米国国立医学図書館(NLM)

Moexipril Hydrochloride: A New Angiotensin Converting Enzyme Inhibitor

This study presents a comprehensive exploration of moexipril hydrochloride, a novel angiotensin converting enzyme (ACE) inhibitor, investigating its pharmacological and toxicological properties. The researchers delve into its in vitro and in vivo effects, examining its potency, selectivity, and safety profile.

Moexipril: A Promising Candidate for Hypertension

The study demonstrates the potent ACE-inhibiting activity of moexipril, both in vitro and in vivo. Moexipril effectively lowers blood pressure in various models of hypertension, highlighting its potential as a therapeutic agent for managing high blood pressure. The study also reveals a favorable safety profile, with no significant side effects observed in the tested models.

Managing Hypertension

Hypertension is a major public health concern, increasing the risk of heart disease, stroke, and kidney failure. Effective management of hypertension is crucial for preventing these complications. This study highlights the potential of moexipril as a new tool in the fight against hypertension, offering hope for improved treatment options.

Dr.Camel's Conclusion

This study provides compelling evidence for the efficacy and safety of moexipril hydrochloride as a new ACE inhibitor. Its potent ACE-inhibiting activity and favorable safety profile suggest a promising future for moexipril in the management of hypertension. Further research is needed to explore its long-term effects and optimize its use in clinical practice.

Date :
  1. Date Completed 1997-05-01
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

9079232

DOI: Digital Object Identifier

9079232

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PICO Info
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Languages

English

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