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Growing placebo response rate: the problem in recent therapeutic trials?

Author: MatuzasW, ThompsonP M, UhlenhuthE H, WarnerT D

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study examined the effect of treatment on panic disorder, finding that medications (alprazolam and imipramine) were more effective for people with more frequent panic attacks at the start of the study. The medications were less effective in addressing more cognitive aspects of panic disorder, such as fear of situations and phobias, suggesting that these medications may not be the best choice for these types of symptoms. The study highlights the importance of considering individual factors and the specific symptoms of panic disorder when choosing treatment options.
Paper Details　
Original Abstract of the Article :
Recently the development of several promising new compounds for anxiety and depression was discontinued because of difficulty demonstrating therapeutic effects. This article explores alternatives to "increasing placebo response rate" as explanations. We reanalyzed a study of 81 panic patients treate...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9133749

データ提供：米国国立医学図書館（NLM）

Growing Placebo Response Rate: A Shifting Landscape in the Desert of Therapeutic Trials

Greetings from Dr. Camel, your guide through the ever-changing desert of therapeutic research. This article explores the challenges of demonstrating therapeutic effects in clinical trials, particularly in the context of anxiety and depression. The researchers investigate the potential role of placebo response rate and its impact on the interpretation of trial results. Their analysis sheds light on the complexities of designing and interpreting clinical trials, offering valuable insights into the ever-evolving landscape of therapeutic research.

Placebo Response Rate: A Shifting Sand Dune in the Desert

The researchers reanalyze a study of 81 panic patients treated with placebo, alprazolam, or imipramine, examining the effect of baseline pathology and treatment on various aspects of panic disorder. Their analysis suggests that the regression of endpoint on baseline number of spontaneous panic attacks differed among treatment groups, with lower slopes for the more active compounds. This indicates that patients with higher baseline panic attack frequency may benefit more from active treatment. It's like witnessing a shifting sand dune in the desert - where the dynamics of treatment response can vary depending on the initial state of the system.

The Desert of Therapeutic Research: Navigating the Shifting Sands

This article highlights the importance of carefully considering the factors that can influence placebo response rate in clinical trials. It emphasizes the need for rigorous study designs and comprehensive analyses to ensure accurate interpretation of results. Just like navigating a desert landscape, where the terrain is constantly shifting, therapeutic research requires a flexible and adaptive approach to effectively address the complexities of human health and disease.

Dr. Camel's Conclusion

The desert of therapeutic research is vast and complex, with many challenges and uncertainties. This article provides valuable insights into the dynamics of placebo response rate, reminding us that the landscape of therapeutic research is constantly evolving. As we continue to explore this desert, we must be vigilant in our pursuit of reliable and effective treatments, ensuring that our research methods are robust and our interpretations are sound.

Date :
  1. Date Completed 1997-05-29
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9133749

DOI: Digital Object Identifier

9133749

Related Literature

Article Analysis
・Effective treatment of panic disorder
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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