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Risk factors for local recurrence after conservative treatment in stage I breast cancer. Definition of a subgroup not requiring radiotherapy.

Author: BerghJ, HolmbergL, LiljegrenG, LindgrenA, NordgrenH, TabárL

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Low age, comedo and lobular cancers, and mammographic appearance of the tumor as a stellate lesion with microcalcifications inside the lesion indicate an increased risk for local recurrence after sector resection in stage 1 tumors at five years. Patients > 60 years of age without comedo or lobular cancers are at low risk for local recurrence at five years even without postoperative radiotherapy.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Risk factors for local recurrence after breast-conserving treatment of early breast cancer have not previously been evaluated in settings where mammography has been a major pathway to diagnosis of both primary tumour and recurrences or in patients treated surgically by a formal sector re...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://pubmed.ncbi.nlm.nih.gov/9137791

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Stage 1 Breast Cancer Recurrence

Like a seasoned traveler navigating a vast desert, researchers are constantly seeking new knowledge to guide patients through the complex terrain of breast cancer. This study, like a well-worn trail, delves into the risk factors for local recurrence after breast-conserving treatment for stage 1 breast cancer. The study aimed to identify a subgroup of patients who might not require postoperative radiotherapy.

Identifying Subgroups for Tailored Treatment

The study revealed that comedo cancer, lobular cancers, and specific mammographic appearances were associated with an increased risk of local recurrence. However, patients over 60 years of age without comedo or lobular carcinomas were found to be at low risk for local recurrence, even without postoperative radiotherapy. These findings offer a crucial guide for treatment decisions, enabling us to better tailor care to the individual needs of each patient.

A Guiding Star for Treatment Decisions

This study provides a valuable tool for clinicians, helping them to identify patients who may benefit from postoperative radiotherapy while also identifying those who may not require this treatment. This tailored approach ensures that each patient receives the most appropriate care, contributing to better outcomes and a more personalized journey through treatment.

Dr.Camel's Conclusion

Just as the desert landscape can vary, so too can the risk of recurrence for Stage 1 breast cancer patients. This study offers a roadmap for navigating this terrain, helping to identify those who may benefit from postoperative radiotherapy while also providing reassurance to those who may not require this treatment. This personalized approach ensures that each patient receives the most appropriate care, contributing to better outcomes and a more personalized journey through treatment.

Date :
  1. Date Completed 1997-07-21
  2. Date Revised 2020-02-03
Further Info :

Pubmed ID

9137791

DOI: Digital Object Identifier

S0923-7534(19)60507-7

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・Effective treatment of breast cancer
SNS
PICO Info
in preparation
Languages

English

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