Paper Details

  1. Home
  2. Paper Details

Heterogeneity of the inhibitory influence of sulfonylureas on prostanoid-induced smooth muscle contraction.

Author: DelaeyC, Van de VoordeJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Sulfonylureas, commonly used to treat diabetes, were found to inhibit prostanoid-induced vasoconstriction across different blood vessel types and species. This effect was observed for all tested sulfonylureas, suggesting a potential benefit in preventing vasoconstriction, but further research is required to understand the mechanism and clinical relevance.
Paper Details　
Original Abstract of the Article :
In addition to their hypoglycemic influence, sulfonylureas have been reported to inhibit prostanoid-induced vasoconstriction. Using isometric tension measurements we investigated whether this inhibitory influence is exerted by different sulfonylureas in various types of blood vessels from different ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/s0014-2999(97)00097-6

データ提供：米国国立医学図書館（NLM）

Sulfonylureas: A Diverse Influence on Smooth Muscle Contraction

This study investigates the effects of sulfonylureas, a type of medication used to treat diabetes, on smooth muscle contraction. Think of it as studying the intricate dance of muscles in a camel's body and how different substances can influence their movements. This research explores the complex interactions between these medications and the body's smooth muscle, shedding light on potential side effects and therapeutic applications.

The study found that sulfonylureas have a varied effect on smooth muscle contraction, depending on the type of muscle, the species, and the specific drug. This is like discovering that different types of camels react differently to various types of desert plants. This complex interplay highlights the need for careful consideration when prescribing these medications to patients.

The Importance of Understanding Drug Interactions

This study underscores the importance of understanding the complex interactions between drugs and the body. It's a reminder that the desert of pharmacology is vast and full of hidden pathways that can lead to unexpected outcomes. This research helps us navigate this intricate landscape and understand the potential side effects of medications, ensuring that patients receive the most appropriate and effective treatment.

Implications for Drug Development

This research provides valuable insights for drug developers, highlighting the importance of considering the potential effects of medications on various tissues and organs. It's like understanding the diverse effects of different types of desert plants on a camel's body, informing the development of more targeted and effective medicines.

Dr. Camel's Conclusion

This study serves as a reminder that even in the vast desert of pharmacology, there is always more to discover. By diligently exploring the interactions between drugs and the body, we can develop more effective and safer medications, improving the health and well-being of patients worldwide.

Date :
  1. Date Completed 1997-08-11
  2. Date Revised 2019-06-24
Further Info :

Pubmed ID

9151937

DOI: Digital Object Identifier

10.1016/s0014-2999(97)00097-6

Related Literature

Article Analysis
・Effects of tolazamide
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.