Treatment of early rheumatoid arthritis with minocycline or placebo: results of a randomized, double-blind, placebo-controlled trial.

Author: BlakelyK, ChurchillM, DietzF, DoudD, DrymalskiW, EckhoffP J, EriksonN, HaireC E, KlassenL W, MaloleyP, MooreG F, O'DellJ R, OlsonR, PalmerW, WeaverA, WeesS

Paper Details 
Original Abstract of the Article :
OBJECTIVE: To determine if minocycline is an effective therapy for seropositive rheumatoid arthritis (RA) when used within the first year of disease. METHODS: The Rheumatoid Arthritis Investigational Network enrolled 46 patients with RA of <1 year duration into a 6-month study of minocycline (100 m...See full text at original site
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引用元:
https://doi.org/10.1002/art.1780400510

データ提供:米国国立医学図書館(NLM)

Minocycline for Early Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory disease, like a desert storm that relentlessly attacks the joints. This research investigates the effectiveness of minocycline, an antibiotic, in treating early seropositive RA. The authors conducted a randomized, double-blind, placebo-controlled trial to compare the efficacy of minocycline to placebo in patients with RA of less than one year duration. Their findings provide insights into the potential therapeutic benefits of minocycline in this patient population.

Minocycline: A Potential Treatment for Early RA?

The study found that minocycline was significantly superior to placebo in improving symptoms of early seropositive RA. A greater proportion of patients treated with minocycline achieved a 50% improvement in symptoms and maintained this improvement for six months. These results suggest that minocycline may offer a valuable treatment option for patients with early RA, potentially slowing disease progression and improving quality of life.

Implications for RA Treatment and Disease Management

This research highlights the potential of minocycline as a therapeutic agent for early RA. The study's findings suggest that minocycline may offer a valuable treatment option for patients with early RA, potentially slowing disease progression and improving quality of life. However, further research is needed to confirm these findings and explore the long-term efficacy and safety of minocycline in treating RA. Like a camel seeking respite from the desert heat, patients with RA need effective treatments to manage their symptoms and improve their quality of life.

Dr.Camel's Conclusion

This research offers a glimmer of hope in the desert of RA, suggesting that minocycline may be a valuable treatment option for early-stage disease. Further research is crucial to confirm these findings and explore the long-term benefits of this promising therapy.

Date :
  1. Date Completed 1997-05-29
  2. Date Revised 2022-03-18
Further Info :

Pubmed ID

9153544

DOI: Digital Object Identifier

10.1002/art.1780400510

Related Literature

SNS
PICO Info
in preparation
Languages

English

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