Pharmacokinetics and safety of single intravenous and oral doses of dolasetron mesylate in healthy women.

Author: CastlesM, DempseyE E, DimmittD, GossardD, JuneauM, KeungA C, LandriaultH, LefebvreM, RobertsL, SpenardJ

Paper Details 
Original Abstract of the Article :
Twenty-four healthy women received 2.4 mg kg-1 dolasetron mesylate (1.8 mg kg-1 dolasetron base) by a 10 min intravenous administration and by oral administration. Pharmacokinetics of dolasetron and of its active reduced metabolite MDL 74156 were monitored for 48 h in plasma. Urine was collected fro...See full text at original site
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引用元:
https://doi.org/10.1002/(sici)1099-081x(199705)18:4<361::aid-bdd25>3.0.co;2-i

データ提供:米国国立医学図書館(NLM)

Dolasetron Mesylate: A Safe and Effective Antiemetic for Women

This study investigates the pharmacokinetics and safety of dolasetron mesylate, an antiemetic medication used to prevent nausea and vomiting, in healthy women. The researchers administered single intravenous and oral doses of dolasetron mesylate to 24 healthy women and monitored the drug's pharmacokinetic profile and safety parameters. The study found that dolasetron was rapidly reduced to its active metabolite, MDL 74156, and that the pharmacokinetic profile of dolasetron was similar in women and men. The study also found that dolasetron was generally well-tolerated, with only mild to moderate side effects observed. This research provides valuable insights into the safety and efficacy of dolasetron mesylate in women, offering reassurance for clinicians prescribing this medication to female patients. This study is like a map guiding us through the desert of antiemetic research, revealing a safe and effective option for women experiencing nausea and vomiting.

Dolasetron: A Safe Oasis in the Desert of Nausea and Vomiting

The study's findings suggest that dolasetron mesylate is a safe and effective antiemetic option for women, providing relief from nausea and vomiting without significant side effects. This research is a testament to the ongoing efforts to develop safe and effective treatments for women experiencing nausea and vomiting, offering a potential solution to a condition that can significantly impact quality of life. This study is a reminder that even in the vast desert of healthcare, there are many hidden oases of relief waiting to be discovered.

Expanding Treatment Options for Women

This research highlights the importance of considering the unique needs of women in the development and evaluation of medications. The study's findings provide valuable insights into the pharmacokinetics and safety profile of dolasetron mesylate in women, offering reassurance for clinicians and expanding treatment options for female patients. This research is a reminder that in the vast desert of healthcare, we must continuously strive to develop treatments that are safe and effective for all individuals.

Dr.Camel's Conclusion

The study's findings suggest that dolasetron mesylate is a safe and effective antiemetic option for women. This research is a testament to the ongoing efforts to develop safe and effective treatments for women experiencing nausea and vomiting, offering a potential solution to a condition that can significantly impact quality of life.

Date :
  1. Date Completed 1997-07-18
  2. Date Revised 2019-10-24
Further Info :

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Languages

English

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