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Concomitant radiotherapy and chemotherapy is superior to radiotherapy alone in the treatment of locally advanced anal cancer: results of a phase III randomized trial of the European Organization for Research and Treatment of Cancer Radiotherapy and Gastrointestinal Cooperative Groups.

Author: BartelinkH, BossetJ F, EschwegeF, GonzalezD G, PeiffertD, PierartM, RoelofsenF, RougierP, van GlabbekeM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Adding chemotherapy to radiotherapy in patients with locally advanced anal cancer significantly increased the complete remission rate from 54% to 80%, improved locoregional control by 18% at 5 years, and reduced the need for colostomy by 32% at 5 years. The 5-year survival rate was 56% for the whole patient group.
Paper Details　
Original Abstract of the Article :
PURPOSE: To investigate the potential gain of the concomitant use of radiotherapy and chemotherapy in improving local control and reducing the need for colostomy, a randomized phase III trial was performed in patients with locally advanced anal cancer. MATERIALS AND METHODS: From 1987 to 1994, 110 ...See full text at original site
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引用元：
https://doi.org/10.1200/JCO.1997.15.5.2040

データ提供：米国国立医学図書館（NLM）

Conquering Anal Cancer: Combining Chemotherapy and Radiotherapy

This research delves into the world of anal cancer treatment, a challenging terrain where the stakes are high. The study examines the effectiveness of combining radiotherapy with chemotherapy in treating locally advanced anal cancer. It's like a team of camels working together, one carrying the load of radiation therapy and the other equipped with chemotherapy, to conquer the harsh desert of cancer.

A Powerful Partnership: The Synergistic Effect of Treatment

The study found that this combined approach led to significantly higher complete remission rates compared to radiotherapy alone. It's as if the combined forces of radiation and chemotherapy create a powerful synergy, like a synchronized team of camels working together to overcome an obstacle. This finding suggests that this combination therapy offers a more effective approach to combatting anal cancer.

Navigating the Terrain: Side Effects and Long-term Outcomes

The study also looked at the side effects of this combined therapy, finding no significant difference in severe adverse effects compared to radiotherapy alone. However, they did note a higher incidence of anal ulcers in the combined-treatment arm. It's like navigating a desert where one path might be smoother, but the other might offer a quicker route, even with some potential challenges along the way. The study highlights the need for careful monitoring and management of side effects to ensure optimal patient outcomes.

Dr. Camel's Conclusion

This research is a significant step in our quest to effectively treat anal cancer. It suggests that combining radiotherapy and chemotherapy can significantly improve the likelihood of achieving remission. It's like discovering a new, more efficient route through the desert, offering hope and better outcomes for patients battling this challenging disease.

Date :
  1. Date Completed 1997-06-16
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

9164216

DOI: Digital Object Identifier

10.1200/JCO.1997.15.5.2040

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Languages

English

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