Trazodone and triazolam: acute subject-rated and performance-impairing effects in healthy volunteers.

Author: GoldmanN H, HayesC A, JohnsonC A, MadakasiraS, PazzagliaP J, RushC R

Paper Details 
Original Abstract of the Article :
The present study compared the acute subject-rated and performance-impairing effects of trazodone and triazolam in seven healthy humans. Trazodone (50, 100 and 200 mg), triazolam (0.125, 0.25, 0.50 mg) and placebo were administered orally in a double-blind, crossover design. Drug effects were measur...See full text at original site
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引用元:
https://doi.org/10.1007/s002130050259

データ提供:米国国立医学図書館(NLM)

Trazodone vs. Triazolam: Comparing Sedative Effects

Trazodone and triazolam are medications commonly used for treating insomnia, but their effects on sedation and cognitive function can vary. This study compared the acute subject-rated and performance-impairing effects of trazodone and triazolam in healthy volunteers. The researchers administered different doses of each medication and assessed their effects on self-reported feelings, sedation, and cognitive performance.

Trazodone Shows Potential as an Alternative

The study's findings, like a desert traveler comparing different paths to reach a destination, reveal that trazodone and triazolam produced comparable levels of sedation, but trazodone had fewer adverse cognitive effects. This research, like a map highlighting a safer route through a treacherous desert, suggests that trazodone may be a viable alternative to benzodiazepine hypnotics like triazolam, especially when minimizing cognitive impairment is a priority.

Choosing the Right Sedative

The research underscores the importance of carefully considering the effects of sedatives on cognitive function, particularly in individuals who need to remain alert and functional. Like a desert traveler carefully choosing the best time to cross a sandstorm, selecting the right sedative can make a significant difference in managing sleep issues without compromising daytime alertness. It's crucial to discuss treatment options with a healthcare professional to determine the best medication for individual needs.

Dr. Camel's Conclusion

This research, like a camel caravan meticulously navigating a desert landscape, compares the effects of trazodone and triazolam, two common sedatives. The study's findings, like a desert oasis offering different types of respite, suggest that trazodone may be a preferable option for some patients seeking to manage sleep issues while minimizing cognitive impairment. Remember, like a wise camel choosing a safe path through the desert, making informed decisions about medication choices can significantly impact our well-being and overall quality of life.

Date :
  1. Date Completed 1997-07-21
  2. Date Revised 2019-07-26
Further Info :

Pubmed ID

9181630

DOI: Digital Object Identifier

10.1007/s002130050259

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Languages

English

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