Effects of deflazacort immunosuppression on long-term growth and growth factors after renal transplantation.

Author: FerrarisJ R, JasperH, PasqualiniT, PennisiP

Paper Details 
Original Abstract of the Article :
Deflazacort is an oxazoline compound derived from prednisolone. We studied changes in kidney function, growth velocity, weight/height ratio, insulin-like growth factor (IGF-I), and IGF binding proteins before and after substitution of deflazacort for methylprednisone in 27 transplanted patients aged...See full text at original site
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引用元:
https://doi.org/10.1007/s004670050285

データ提供:米国国立医学図書館(NLM)

Deflazacort: A Promising Immunosuppressant for Children After Renal Transplant

Renal transplantation, the process of replacing a failing kidney with a donor kidney, is a life-saving treatment for patients with kidney failure. Immunosuppressant medications are essential after transplantation to prevent the body from rejecting the donor kidney. This study, like a group of physicians seeking a safe and effective treatment for their patients, explores the effects of deflazacort, an immunosuppressant, on the long-term growth of children after renal transplantation.

Deflazacort: A Growth-Promoting Oasis in the Desert of Immunosuppression

The study found that deflazacort was as effective as methylprednisolone in suppressing the immune system and maintaining kidney function. Moreover, deflazacort was associated with an improvement in growth velocity in prepubertal patients, suggesting that this medication could help minimize the growth-suppressing effects of other immunosuppressants. This discovery is like finding a hidden oasis in the desert, offering a potential solution to a common challenge for children after renal transplantation.

A Brighter Future for Children After Transplant

The study's findings offer hope for children who have undergone renal transplantation, demonstrating the potential of deflazacort to both suppress the immune system and promote growth. This discovery is like a ray of sunlight breaking through the clouds in the desert, offering a more optimistic outlook for these children. The study's findings emphasize the importance of carefully considering the individual needs of each patient and choosing the most appropriate immunosuppressant medication.

Dr.Camel's Conclusion

This study suggests that deflazacort may be a promising immunosuppressant for children after renal transplantation, offering both effective immune suppression and potential growth promotion. The findings provide valuable insights into the long-term effects of deflazacort on growth and suggest that it may be a valuable option for children who require immunosuppressive therapy after transplantation.

Date :
  1. Date Completed 1997-09-03
  2. Date Revised 2019-09-05
Further Info :

Pubmed ID

9203181

DOI: Digital Object Identifier

10.1007/s004670050285

Related Literature

SNS
PICO Info
in preparation
Languages

English

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