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Apafant (a PAF receptor antagonist) suppresses the early and late airway responses in guinea pigs: a comparison with antiasthmatic drugs.
Author: FuchigamiJ, HataH, IkegamiK, KohjimotoY, TanakaK, TasakaK, UchidaS
Original Abstract of the Article :
We studied the effects of apafant (WEB 2086 BS), a specific and potent platelet activating factor (PAF) receptor antagonist, on the early and late airway responses in conscious and actively sensitized guinea pigs. An increase in airway resistance (Rs) was seen 1 min after the inhaled antigen challen...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/s0014-2999(97)83031-2
データ提供:米国国立医学図書館(NLM)
Apafant: A New Weapon Against Asthma
Asthma, a chronic inflammatory disease, affects millions worldwide. This study explores the potential of [apafant, a PAF receptor antagonist] as a novel treatment option for asthma. The authors investigated the effects of apafant on both the [early and late airway responses] in guinea pigs, comparing it to the effectiveness of other commonly used anti-asthmatic drugs. This research provides valuable insights into the therapeutic potential of apafant and its role in managing asthma symptoms.
Apafant: A Promising New Anti-Asthma Agent
The study's findings suggest that apafant is highly effective in [inhibiting both the early and late airway responses] in guinea pigs. This suggests that apafant could potentially offer a more comprehensive approach to asthma management compared to other drugs that only target specific phases of the response. The study also found that apafant was comparable or superior to other anti-asthmatic drugs in its effectiveness.
Managing Asthma: A Multifaceted Approach
This research highlights the importance of [targeting multiple pathways] involved in asthma development. By blocking the PAF receptor, apafant may offer a more comprehensive approach to asthma management. The findings of this study suggest that apafant could be a valuable addition to the arsenal of drugs available for treating asthma.
Dr.Camel's Conclusion
This study provides a fascinating glimpse into the intricate world of asthma and the potential of apafant to improve treatment outcomes. As researchers continue to explore the desert of asthma research, we can expect to discover even more innovative and effective treatments for this challenging condition.
Date :
- Date Completed 1998-01-06
- Date Revised 2019-06-24
Further Info :
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