Apafant (a PAF receptor antagonist) suppresses the early and late airway responses in guinea pigs: a comparison with antiasthmatic drugs.

Author: FuchigamiJ, HataH, IkegamiK, KohjimotoY, TanakaK, TasakaK, UchidaS

Paper Details 
Original Abstract of the Article :
We studied the effects of apafant (WEB 2086 BS), a specific and potent platelet activating factor (PAF) receptor antagonist, on the early and late airway responses in conscious and actively sensitized guinea pigs. An increase in airway resistance (Rs) was seen 1 min after the inhaled antigen challen...See full text at original site
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引用元:
https://doi.org/10.1016/s0014-2999(97)83031-2

データ提供:米国国立医学図書館(NLM)

Apafant: A New Weapon Against Asthma

Asthma, a chronic inflammatory disease, affects millions worldwide. This study explores the potential of [apafant, a PAF receptor antagonist] as a novel treatment option for asthma. The authors investigated the effects of apafant on both the [early and late airway responses] in guinea pigs, comparing it to the effectiveness of other commonly used anti-asthmatic drugs. This research provides valuable insights into the therapeutic potential of apafant and its role in managing asthma symptoms.

Apafant: A Promising New Anti-Asthma Agent

The study's findings suggest that apafant is highly effective in [inhibiting both the early and late airway responses] in guinea pigs. This suggests that apafant could potentially offer a more comprehensive approach to asthma management compared to other drugs that only target specific phases of the response. The study also found that apafant was comparable or superior to other anti-asthmatic drugs in its effectiveness.

Managing Asthma: A Multifaceted Approach

This research highlights the importance of [targeting multiple pathways] involved in asthma development. By blocking the PAF receptor, apafant may offer a more comprehensive approach to asthma management. The findings of this study suggest that apafant could be a valuable addition to the arsenal of drugs available for treating asthma.

Dr.Camel's Conclusion

This study provides a fascinating glimpse into the intricate world of asthma and the potential of apafant to improve treatment outcomes. As researchers continue to explore the desert of asthma research, we can expect to discover even more innovative and effective treatments for this challenging condition.

Date :
  1. Date Completed 1998-01-06
  2. Date Revised 2019-06-24
Further Info :

Pubmed ID

9203572

DOI: Digital Object Identifier

10.1016/s0014-2999(97)83031-2

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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