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Behavioral effects of liothyronine (L-T3) in children with attention deficit hyperactivity disorder in the presence and absence of resistance to thyroid hormone.

Author: RefetoffS, SteinM A, WeissR E

Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Liothyronine treatment was found to be beneficial in reducing hyperactivity and impulsivity in children with ADHD and resistance to thyroid hormone. However, in children with ADHD without RTH, L-T3 had no effect or may be detrimental.
Paper Details　
Original Abstract of the Article :
Evidence that the thyroid may play a role in the pathogenesis of attention deficit hyperactivity disorder (ADHD) comes from observations that 48% to 73% of children with the syndrome of resistance to thyroid hormone (RTH) have ADHD. Casual observations in subjects with RTH have suggested that treatm...See full text at original site
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引用元：
https://doi.org/10.1089/thy.1997.7.389

データ提供：米国国立医学図書館（NLM）

Thyroid Hormone: A Potential Link to ADHD?

Attention deficit hyperactivity disorder (ADHD), a common neurodevelopmental disorder, can significantly affect a child's behavior and academic performance. It's like a desert mirage, creating a sense of disorientation and difficulty focusing. This study, like a desert expedition team, explores the potential role of thyroid hormone in ADHD. The researchers, like skilled desert explorers, investigate the connection between thyroid function and ADHD, particularly in children with resistance to thyroid hormone (RTH).

Thyroid Hormone: A Possible Influence on ADHD Symptoms

The researchers, like astute desert observers, discovered that liothyronine (L-T3), a rapid-acting thyroid hormone, had a positive effect on hyperactivity and impulsivity in children with ADHD and RTH, but not in children with ADHD without RTH. This finding, like a desert oasis revealing its secrets, suggests that thyroid hormone may play a role in ADHD symptoms, especially in those with RTH.

Individualized Treatment: A Personalized Approach

This study, like a camel caravan adapting to the changing desert landscape, highlights the importance of individualized treatment for children with ADHD. It suggests that thyroid hormone therapy may be a valuable option for some children with ADHD and RTH, but not for all. This underscores the need for careful assessment and personalized treatment plans to optimize outcomes for each child.

Dr.Camel's Conclusion

This study, like a well-worn desert trail, guides us towards a greater understanding of the complex relationship between thyroid function and ADHD. It emphasizes the need for individualized treatment approaches, acknowledging that each child is unique and requires a tailored strategy to achieve optimal health and well-being. The findings encourage us to continue exploring the intricate connections between our bodies and our brains, uncovering new insights to support children with ADHD and their families.
Date :
  1. Date Completed 1997-09-17
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9226208

DOI: Digital Object Identifier

10.1089/thy.1997.7.389

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・Effects of liothyronine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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