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Evaluation of phototoxic properties of oral antidiabetics and diuretics. Photohemolysis model as a screening method for recognizing potential photosensitizing drugs.

Author: SelvaagE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the photohemolytic properties of various oral hypoglycemic drugs and diuretics in vitro. Exposure to UVA or visible light, but not UVB, caused hemolysis in the presence of five oral hypoglycemic agents and 19 out of 25 diuretics. This suggests that the in vitro photohemolysis model can be a good predictor of photosensitizing sulfonamides.
Paper Details　
Original Abstract of the Article :
The oral hypoglycemic drugs carbutamide, chlorpropamide, glibenclamide, glubornuride, gliclazide, glipizide, gliquidone, glisoxepide, glymidine, tolazamide and tolbutamide, and the diuretics acetazolamide, bemetizide, bendroflumethiazide, benzthiazide, benzylhydrochlorothiazide, bumetanide, butizide...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9342417

データ提供：米国国立医学図書館（NLM）

Phototoxic Properties of Oral Antidiabetics and Diuretics

This research investigates the phototoxic properties of various oral antidiabetic and diuretic medications. The authors, like skilled chemists studying the properties of different compounds, explored the potential of these medications to cause photosensitivity reactions when exposed to ultraviolet (UV) light. They conducted a series of experiments to assess the photohemolytic properties of these drugs using an in vitro model.

The Phototoxic Potential of Certain Medications

This research reveals the phototoxic potential of certain oral antidiabetic and diuretic medications. The authors found that several of these medications, when exposed to UV light, can induce hemolysis (red blood cell destruction). These findings highlight the importance of considering the potential for photosensitivity reactions when prescribing these drugs.

Safe Medication Use and Sun Protection

This research underscores the importance of considering photosensitivity reactions when prescribing medications. The authors emphasize the need for healthcare providers to inform patients about the potential risks of photosensitivity and to advise them to take appropriate precautions, such as sun protection. Imagine a group of travelers crossing a scorching desert. Just as they must protect themselves from the sun's intense rays, individuals taking certain medications must be aware of the potential risks of photosensitivity and take steps to protect themselves.

Dr. Camel's Conclusion

This research highlights the importance of considering the phototoxic potential of medications, particularly those containing sulfonamides. The study emphasizes the need for healthcare providers to inform patients about the potential risks of photosensitivity and to recommend appropriate sun protection measures.
Date :
  1. Date Completed 1997-12-08
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

9342417

DOI: Digital Object Identifier

9342417

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PICO Info
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Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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