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Extrapyramidal side effects with risperidone and haloperidol at comparable D2 receptor occupancy levels.

Author: HeinzA, KnableM B, RaedlerT, WeinbergerD R

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study compared the D2 receptor occupancy and clinical effects of risperidone and haloperidol in subjects treated with routine clinical doses. Both drugs produced similar D2 occupancy levels and rates of drug-induced parkinsonism, suggesting that 5-HT2 blockade with risperidone does not protect against extrapyramidal side effects.
Paper Details　
Original Abstract of the Article :
Risperidone is an antipsychotic drug with high affinity at dopamine D2 and serotonin 5-HT2 receptors. Previous clinical studies have proposed that risperidone's pharmacologic profile may produce improved efficacy for negative psychotic symptoms and decreased propensity for extrapyramidal side effect...See full text at original site
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引用元：
https://doi.org/10.1016/s0925-4927(97)00023-1

データ提供：米国国立医学図書館（NLM）

Risperidone and Haloperidol: A Tale of Two Antipsychotics

The world of antipsychotics is a complex landscape, with different medications offering unique pathways to manage mental health conditions. This study investigates the effects of risperidone and haloperidol, two commonly used antipsychotics, on dopamine D2 receptor occupancy and the occurrence of extrapyramidal side effects. It's like comparing two camels navigating different routes across the desert, each encountering different terrain and obstacles.

Similar Occupancy, Different Side Effects

The study reveals that risperidone and haloperidol, despite producing similar levels of dopamine D2 receptor occupancy, exhibit distinct patterns of side effects. It's like finding that two camels, traversing similar desert landscapes, encounter different challenges based on their unique routes and adaptations. This research suggests that the differences in side effects may be attributed to the additional serotonin 5-HT2 receptor blockade provided by risperidone.

Understanding the Nuances of Antipsychotic Therapy

This research highlights the need for a nuanced understanding of antipsychotic therapy, taking into account the individual variations in drug response and potential side effects. It's like recognizing that different camels are better suited for different desert terrains, and that choosing the right medication for each patient is crucial for optimal outcomes.

Dr.Camel's Conclusion

The journey of treating mental health conditions is often complex and requires careful consideration of individual needs. This study underscores the importance of understanding the nuances of antipsychotic therapy and choosing the medication that best aligns with each patient's unique characteristics. It's a reminder that navigating the challenging terrain of mental health requires a personalized approach, much like selecting the right camel for a specific desert journey.

Date :
  1. Date Completed 1997-12-16
  2. Date Revised 2019-08-26
Further Info :

Pubmed ID

9351491

DOI: Digital Object Identifier

10.1016/s0925-4927(97)00023-1

Related Literature

Article Analysis
・Side Effects of risperidone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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