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Clarithromycin, amoxycillin and H2-receptor antagonist therapy for Helicobacter pylori peptic ulcer disease in Korea.

Author: BreuerT, GrahamD Y, KimJ G, NakajimaS, NikajimaS, OsatoM, OtaH, el-ZimaityH M

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Overview

A 10-day twice-daily quadruple therapy with lansoprazole, tetracycline, metronidazole, and bismuth was effective for metronidazole-sensitive H. pylori infection, but less effective for resistant strains.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Effective anti-Helicobacter pylori therapies with few side-effects are needed. We previously showed that the regimen of amoxycillin, clarithromycin and an H2-receptor antagonist was effective in the United States. The current study tested whether this therapy would also be successful in ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://doi.org/10.1046/j.1365-2036.1997.00233.x

データ提供：米国国立医学図書館（NLM）

Helicobacter pylori Treatment: A Quest for Effective Strategies

Helicobacter pylori infection is a common foe, a tenacious desert dweller that can wreak havoc on the digestive system. This study explores the effectiveness of a triple therapy regimen, combining amoxycillin, clarithromycin, and an H2-receptor antagonist, in treating H. pylori-related peptic ulcer disease in Korean patients.

The researchers conducted a clinical trial involving 72 patients, comparing the effectiveness of this therapy in Korean patients to its previously reported success in the United States. It's like studying the effectiveness of different irrigation methods in a desert oasis, comparing their impact on different regions of the landscape.

A Successful Oasis in the Desert of H. pylori

The results showed a high cure rate of 95.8% in the Korean patients, indicating that this triple therapy regimen is effective in treating H. pylori infection in this population. It's like discovering a reliable source of water in a desert, offering a solution to a persistent problem.

Navigating the Desert of H. pylori Treatment

This study underscores the importance of finding effective and culturally relevant treatment strategies for H. pylori infection. It's a reminder that the desert of H. pylori can be vast and challenging, but with dedicated research and collaboration, we can find oases of hope and healing for those affected by this infection.

Dr. Camel's Conclusion

This study demonstrates the efficacy of a specific triple therapy regimen in treating H. pylori infection in Korean patients, providing a beacon of hope in the desert of H. pylori-related disease. It's a reminder that even in the most challenging landscapes, there can be oases of effective treatment waiting to be discovered.

Date :
  1. Date Completed 1997-12-18
  2. Date Revised 2019-08-31
Further Info :

Pubmed ID

9354204

DOI: Digital Object Identifier

10.1046/j.1365-2036.1997.00233.x

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