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The comparative amnestic effects of midazolam, propofol, thiopental, and fentanyl at equisedative concentrations.

Author: FeshchenkoV A, ReinselR A, VeselisR A, WrońskiM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Propofol produces the same degree of memory impairment as midazolam at equal sedation levels. Thiopental has mild memory effects, while fentanyl has no effect. Ondansetron alone has no sedative or amnesic effects.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The authors evaluated the effects of midazolam, propofol, thiopental, and fentanyl on volunteer participants' memory for words and pictures at equisedative concentrations. METHODS: Sixty-seven healthy volunteers were randomized to receive intravenous infusions of midazolam (n = 11), pro...See full text at original site
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引用元：
https://doi.org/10.1097/00000542-199710000-00007

データ提供：米国国立医学図書館（NLM）

Sedatives and Memory: A Balancing Act

In the vast expanse of medicine, we often encounter the delicate balance between therapeutic effects and unwanted side effects. This study delves into the world of sedatives, exploring their impact on memory, akin to a caravan leader carefully navigating a desert landscape with potential dangers lurking around every corner.

The Impact of Sedatives on Memory

The researchers compared the effects of midazolam, propofol, thiopental, and fentanyl on memory, discovering that each drug had a unique effect. Propofol and midazolam were found to have the most significant impact on memory, like a sandstorm obscuring the view ahead. Thiopental had mild memory effects, while fentanyl had none. The study highlights the importance of choosing the right sedative for each patient, considering not only the desired sedation level but also the potential for memory impairment.

Navigating the Terrain of Sedation

This study underscores the importance of careful consideration when using sedatives. Like a wise caravan leader choosing the safest path through a desert, healthcare professionals must weigh the benefits of sedation against the potential risks of memory impairment.

Dr. Camel's Conclusion

Sedatives, like a mirage in the desert, can provide a temporary respite, but they also come with potential drawbacks. This study provides valuable insights into the impact of different sedatives on memory, reminding us to carefully navigate this terrain to minimize the risks and maximize the benefits of these medications.

Date :
  1. Date Completed 1997-11-20
  2. Date Revised 2019-06-28
Further Info :

Pubmed ID

9357875

DOI: Digital Object Identifier

10.1097/00000542-199710000-00007

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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