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Efficacy and side-effects of cyclosporine dose monitoring with levels 6 h after the morning dose in heart transplant patients.

Author: BesnerJ G, CantarovichM, FitchettD H, LatterD A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared CsA dose monitoring with trough levels (T0) vs. levels obtained 6 hours after the morning dose (T6) in heart transplant patients. Monitoring with T6 levels resulted in a lower cumulative CsA dose and cost, without compromising efficacy in preventing acute rejection or affecting cardiac and renal function.
Paper Details　
Original Abstract of the Article :
The purpose of this study was to compare CsA dose monitoring with trough levels (T0) vs. levels obtained 6 h after the morning dose of CsA (T6), with respect to the incidence of acute rejection and renal dysfunction, and the cumulative dose, as well as the cost of CsA after heart transplantation. Tw...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9361930

データ提供：米国国立医学図書館（NLM）

Cyclosporine Dose Monitoring in Heart Transplant Patients

The field of transplantation medicine is constantly seeking to optimize immunosuppressive therapy to prevent rejection and maintain patient health. This study, published in 1998, compares two methods of cyclosporine (CsA) dose monitoring in heart transplant patients: trough levels (T0) versus levels obtained 6 hours after the morning dose (T6). The researchers sought to determine the impact of each method on the incidence of acute rejection, renal function, and overall CsA dosage.

CsA Dose Monitoring: A Balancing Act

Imagine monitoring CsA levels as a delicate balancing act in a desert, where too little or too much can lead to complications. This study shows that CsA dose monitoring with T6 levels resulted in significantly lower overall CsA dosage compared to T0 levels, while maintaining similar effectiveness in preventing acute rejection and preserving renal function.

Navigating the Desert of Immunosuppression

Heart transplant patients, like travelers in a harsh desert, require careful management to navigate the challenges of immunosuppression. This study emphasizes the importance of individualized treatment approaches and the need to optimize drug regimens to minimize side effects and maximize patient outcomes. It highlights the potential benefits of using T6 levels for CsA dose monitoring, offering a promising approach to improving the management of heart transplant patients.

Dr.Camel's Conclusion

This research provides valuable insights into the nuances of CsA dose monitoring in heart transplant patients. The findings suggest that T6 level monitoring may offer a more efficient and effective approach to managing CsA dosage, reducing overall drug exposure and potentially improving patient outcomes. Just as a skilled desert guide adapts their strategies based on the environment, so too must we constantly refine our approaches to immunosuppressive therapy in transplant patients.

Date :
  1. Date Completed 1998-01-26
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9361930

DOI: Digital Object Identifier

9361930

Related Literature

Article Analysis
・Side Effects of cyclosporine
SNS
PICO Info
in preparation
Languages

English

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