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The comparative effects of lansoprazole, omeprazole, and ranitidine in suppressing gastric acid secretion.

Author: BlumR A, Greski-RoseP A, HuntR H, KarolM D, ShiH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Lansoprazole 30 mg QD produced significantly higher mean 24-hour intragastric pH values compared to lansoprazole 15 mg QD, omeprazole 20 mg QD, or ranitidine 150 mg QID in 29 healthy male volunteers. Lansoprazole 30 mg also resulted in significantly greater mean percentages of time that the gastric pH was above 3.0 and 4.0. All treatment regimens were well tolerated.
Paper Details　
Original Abstract of the Article :
The effects on 24-hour intragastric pH levels of once-daily doses of lansoprazole 15 mg and lansoprazole 30 mg were compared with the effects of omeprazole 20 mg QD and ranitidine 150 mg QID in a phase I, randomized, double-masked, four-way crossover study conducted in 29 healthy male volunteers. Su...See full text at original site
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引用元：
https://doi.org/10.1016/s0149-2918(97)80053-7

データ提供：米国国立医学図書館（NLM）
in preparation
Date :
  1. Date Completed 1997-12-30
  2. Date Revised 2019-09-20
Further Info :

Pubmed ID

9385488

DOI: Digital Object Identifier

10.1016/s0149-2918(97)80053-7

SNS
PICO Info
in preparation
Languages

English

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