Reproductive endocrine and endometrial effects of raloxifene hydrochloride, a selective estrogen receptor modulator, in women with regular menstrual cycles.

Author: AllerheiligenS, BakerV L, DraperM, GlantM, JaffeR B, PaulS, ShifrenJ

Paper Details 
Original Abstract of the Article :
Previous studies of raloxifene conducted in animal models and postmenopausal women have demonstrated antiestrogenic action on the endometrium. The purpose of this first study of raloxifene in women with normal menstrual cycles was to determine its reproductive endocrine and endometrial effects. In p...See full text at original site
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引用元:
https://doi.org/10.1210/jcem.83.1.4448

データ提供:米国国立医学図書館(NLM)

Raloxifene's Effects on Women's Cycles: A Desert Oasis of Knowledge

The world of reproductive health is a vast desert, filled with complex interactions and delicate balances. This research delves into the fascinating interplay between raloxifene, a selective estrogen receptor modulator, and the menstrual cycle in women. The study employed a meticulous approach, administering raloxifene in different phases of the cycle and closely observing the effects on hormones and the endometrium. This expedition into the hormonal landscape yielded some intriguing findings, particularly regarding the potential for raloxifene to subtly influence the endometrium.

Raloxifene Doesn't Prevent Ovulation, But It's a Balancing Act

The study revealed that raloxifene, while exhibiting antiestrogenic properties on the endometrium, does not prevent ovulation. This discovery is significant because it suggests that raloxifene's impact on the reproductive system is not as drastic as initially perceived. It's like a delicate balance in a desert ecosystem, where even a seemingly disruptive factor can have a nuanced effect. The study observed that raloxifene can lead to an increase in FSH and estradiol levels, which are key players in ovarian function.

Navigating the Hormonal Desert: Implications for Women's Health

This study sheds light on the intricate relationship between raloxifene and the female reproductive system. While the findings suggest that raloxifene may not be a significant disruptor of ovulation, its potential influence on endometrial health warrants further investigation. As researchers continue to explore the hormonal desert, we can expect to gain valuable insights into the intricate mechanisms governing women's health.

Dr.Camel's Conclusion

This research reminds us that the human body is a complex desert, with intricate ecosystems of hormones and systems. It's vital to understand the delicate balance and the subtle influences of various factors, like raloxifene, to navigate this landscape of health.

Date :
  1. Date Completed 1998-02-09
  2. Date Revised 2022-02-23
Further Info :

Pubmed ID

9435408

DOI: Digital Object Identifier

10.1210/jcem.83.1.4448

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English

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