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Randomized crossover study comparing the phosphate-binding efficacy of calcium ketoglutarate versus calcium carbonate in patients on chronic hemodialysis.

Author: BroS, Feldt-RasmussenB, HandbergJ, OlgaardK, RasmussenR A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Calcium ketoglutarate was found to be an effective and safe alternative to aluminum-containing phosphate binders in patients on hemodialysis who are intolerant to calcium carbonate or acetate due to hypercalcemia. However, it was associated with intolerance in 29% of patients, particularly those with pre-existing gastrointestinal symptoms, and was 10 times more expensive than calcium carbonate.
Paper Details　
Original Abstract of the Article :
The objective of the study was to evaluate the phosphate-binding efficacy, side effects, and cost of therapy of calcium ketoglutarate granulate as compared with calcium carbonate tablets in patients on chronic hemodialysis. The study design used was a randomized, crossover open trial, and the main o...See full text at original site
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引用元：
https://doi.org/10.1053/ajkd.1998.v31.pm9469496

データ提供：米国国立医学図書館（NLM）

Chronic Hemodialysis: Finding the Right Phosphate Binder Oasis

Chronic hemodialysis, a life-sustaining treatment for kidney failure, can feel like navigating a desert of dietary restrictions and medication adjustments. This research investigates the efficacy and safety of calcium ketoglutarate versus calcium carbonate in patients on chronic hemodialysis, focusing on their phosphate-binding capabilities.

Phosphate Binders: A Crucial Oasis in the Desert of Dialysis

The study evaluated the phosphate-binding efficacy, side effects, and cost of therapy for calcium ketoglutarate and calcium carbonate. The researchers found that calcium ketoglutarate was effective in controlling phosphate levels, but it was more expensive and had a higher incidence of gastrointestinal side effects. This research provides valuable insights into the trade-offs associated with different phosphate-binding agents.

Navigating the Desert of Kidney Failure

This research underscores the importance of finding the right balance between efficacy and cost in managing chronic hemodialysis. It highlights the need for personalized treatment plans, taking into account individual needs and preferences. By working closely with healthcare professionals, individuals can navigate the desert of kidney failure more effectively and achieve better overall health outcomes.

Dr.Camel's Conclusion

Navigating the desert of chronic hemodialysis can be a challenging journey, but finding the right phosphate binder oasis can make the journey more manageable. This research highlights the potential of calcium ketoglutarate, but also underscores the need for careful consideration of its cost and side effects. By working closely with healthcare professionals, individuals can find the most effective path for managing their condition and improving their quality of life.

Date :
  1. Date Completed 1998-02-26
  2. Date Revised 2019-08-15
Further Info :

Pubmed ID

9469496

DOI: Digital Object Identifier

10.1053/ajkd.1998.v31.pm9469496

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