Central imidazoline (I1) receptors as targets of centrally acting antihypertensives: moxonidine and rilmenidine.

Author: van ZwietenP A

Paper Details 
Original Abstract of the Article :
Clonidine, guanfacine, guanabenz and alpha-methyl-dioxyphenylalanine (DOPA), the prototypes of centrally acting antihypertensives, are assumed to induce peripheral sympathoinhibition and a reduction in blood pressure via the stimulation of alpha2-adrenoceptors in the brain stem. More recently, centr...See full text at original site
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引用元:
https://doi.org/10.1097/00004872-199715020-00001

データ提供:米国国立医学図書館(NLM)

Central Imidazoline (I1) Receptors: A New Target for Antihypertensives

The realm of [hypertension] is a complex and challenging landscape, much like the seemingly endless dunes of a desert. Finding effective and safe treatment options is crucial for managing this prevalent condition. This research, like a seasoned explorer, delves into the role of [central imidazoline (I1) receptors] as potential targets for [centrally acting antihypertensives]. The authors examine the potential of I1 receptor agonists, such as [moxonidine] and [rilmenidine], to offer a novel approach to hypertension management.

A New Avenue for Hypertension Treatment

The study explores the potential of targeting I1 receptors to reduce blood pressure. This discovery is like finding a hidden spring in the desert, offering a new avenue for managing hypertension. The researchers highlight the potential of I1 receptor agonists to offer a selective approach to blood pressure control, minimizing the side effects associated with traditional alpha2-receptor agonists.

Navigating the Hypertension Desert

This research underscores the importance of exploring new targets and mechanisms for hypertension treatment. It's like navigating a desert with a compass, guiding scientists towards more effective and safer strategies. The study's findings suggest that I1 receptor agonists may offer a promising alternative to traditional approaches, potentially leading to improved outcomes and fewer side effects for patients. This research provides valuable insights into the complex world of hypertension management, opening new doors for therapeutic innovation.

Dr.Camel's Conclusion

This research, like a caravan traversing a desert, reveals the potential of targeting central imidazoline (I1) receptors for hypertension treatment. It underscores the importance of exploring novel mechanisms to develop more effective and safer antihypertensive therapies.

Date :
  1. Date Completed 1998-02-26
  2. Date Revised 2019-08-22
Further Info :

Pubmed ID

9469786

DOI: Digital Object Identifier

10.1097/00004872-199715020-00001

Related Literature

SNS
PICO Info
in preparation
Languages

English

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