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Clinical failure of CMV retinitis with intravitreal cidofovir is associated with antiviral resistance.

Author: AiE, FreemanW R, MuellerA J, PowellH C, RahhalF M, SmithI L, SpectorS A, TaskintunaI

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Clinical resistance to intraocular cidofovir injection for AIDS-related CMV retinitis occurred infrequently but was associated with prior ganciclovir or intravenous cidofovir use and resistant CMV strains.
Paper Details　
Original Abstract of the Article :
OBJECTIVES: To determine the incidence of clinical resistance to intraocular cidofovir injection for treatment of acquired immunodeficiency syndrome (AIDS)-related cytomegalovirus (CMV) retinitis, and to identify virologic features associated with cidofovir treatment failure. PATIENTS AND METHODS: ...See full text at original site
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引用元：
https://doi.org/10.1001/archopht.116.2.178

データ提供：米国国立医学図書館（NLM）

Antiviral Resistance in CMV Retinitis: A Challenging Landscape

Cytomegalovirus (CMV) retinitis, a serious eye infection, can be a formidable foe, like a persistent desert mirage that eludes our attempts to conquer it. This research explores the challenges of treating CMV retinitis, focusing on the development of antiviral resistance to intravitreal cidofovir injections. The study found that prior use of ganciclovir or intravenous cidofovir was associated with the emergence of antiviral resistance, underscoring the need for careful treatment strategies.

Navigating Antiviral Resistance

The study highlights the importance of understanding and addressing the emergence of antiviral resistance, a complex challenge in managing CMV retinitis. Just as a traveler must adapt to changing desert conditions, healthcare providers must carefully monitor treatment responses and adjust strategies to overcome resistance.

Protecting Your Eyes: A Proactive Approach

Maintaining good health is crucial for protecting your vision, particularly when it comes to conditions like CMV retinitis. Regular eye exams and proactive healthcare management can help prevent or manage eye infections effectively. It's like preparing for a desert journey, ensuring you have the necessary tools and knowledge to navigate potential challenges.

Dr.Camel's Conclusion

This research serves as a reminder of the ever-evolving nature of infectious diseases. Just as the desert landscape constantly shifts and changes, so too do the strategies needed to combat these challenges. Understanding the mechanisms of antiviral resistance is crucial for developing effective treatments and improving patient outcomes.

Date :
  1. Date Completed 1998-03-09
  2. Date Revised 2019-07-04
Further Info :

Pubmed ID

9488269

DOI: Digital Object Identifier

10.1001/archopht.116.2.178

Related Literature

Article Analysis
・Effects of cidofovir injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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