Effects of cidofovir injection: A Synthesis of Findings from 11 Studies

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Original Abstract of the Article

Main research findings

Cidofovir injection has shown promising results in treating various conditions, including recurrent respiratory papillomatosis (RRP) and cytomegalovirus (CMV) retinitis. 8 found that 76.9% of RRP patients responded to cidofovir injection and achieved remission. reported that cidofovir was approved by the FDA for treating CMV retinitis. Additionally, 2 demonstrated the effectiveness of low-dose intravitreal cidofovir injections for long-term management of CMV retinitis.

However, some studies have reported unusual complications associated with cidofovir injection. 4 described a case where a patient developed a mucosal bridge and pitting in the true vocal fold after receiving high-dose cidofovir injections. This suggests that repeated high-dose injections may lead to significant morphological changes in the vocal fold due to mucosal injury.

Benefits and Risks

Benefit Summary

Cidofovir injection has the potential to be an effective treatment for conditions like RRP and CMV retinitis, expanding treatment options for these diseases. 8 , , 2 .

Risk Summary

Cidofovir injection can cause rare side effects such as mucosal bridge and pitting in the vocal folds. 4 . Other potential side effects include hepatotoxicity and neutropenia, as reported in 6 . It's crucial to discuss these risks with your doctor before receiving cidofovir injection.

Comparison between Studies

Similarities

These studies highlight the potential effectiveness of cidofovir injection in treating RRP and CMV retinitis. They also suggest that the occurrence and severity of side effects may vary depending on the administration method and dosage of cidofovir.

Differences

The studies differ in their target diseases, administration methods, dosages, and evaluation criteria. Therefore, it's not possible to make a direct comparison of the effectiveness and safety of cidofovir injection across these studies.

Consistency and Contradictions in Results

While research indicates that cidofovir injection may be effective for treating RRP and CMV retinitis, some studies have raised concerns about potential side effects such as vocal fold alterations. 4 . Considering these findings, it's crucial to use cidofovir injection cautiously, weighing its benefits against its potential risks.

Implications for Daily Life

Cidofovir injection should only be used under the guidance of a healthcare professional, ensuring proper administration method and dosage. Remember that side effects can vary from person to person, and not everyone will experience them. It's essential to consult with a doctor before receiving cidofovir injection, discussing potential risks and benefits to make an informed decision about treatment.

Limitations of Current Research

More research is needed to fully understand the long-term safety and efficacy of cidofovir injection. Specifically, long-term studies focusing on its safety and effectiveness are lacking. Additionally, considering the potential variations in administration methods, dosages, and side effect occurrences among individuals, further research is crucial.

Future Research Directions

Future research should focus on investigating the long-term safety and efficacy of cidofovir injection, exploring the relationship between administration method, dosage, and side effects, and conducting personalized studies accounting for individual differences.

Conclusion

Cidofovir injection holds promise as a potential treatment for RRP and CMV retinitis, offering new treatment options. However, it's crucial to use it cautiously due to the possibility of rare side effects like vocal fold alterations. More research is needed to better understand its long-term safety and efficacy. It's vital to consult with a doctor before considering cidofovir injection, discussing potential risks and benefits to make informed decisions about treatment.

Literature analysis of 11 papers
Positive Content
11
Neutral Content
0
Negative Content
0
Article Type
1
0
0
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11
1.

The new topical steroid ciclesonide is effective in the treatment of allergic rhinitis.

Author: SchmidtB M, TimmerW, GeorgensA C, HiltM, MattingerC, WurstW, HörmannK, WehlingM

Allergic rhinitis treatment

A randomized, placebo-controlled, double-blind crossover study was performed to investigate the efficacy of ciclesonide nasal spray in allergic rhinitis at the dose level of 200 micrograms per nostril. Rhinal airflow improved significantly from day 5, while the subjective symptom of obstruction improved from day 2. Itching and rhinorrhea also improved significantly. The local and systemic tolerability of ciclesonide nasal spray was excellent.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

2.

Low-dose intravitreal cidofovir (HPMPC) therapy of cytomegalovirus retinitis in patients with acquired immune deficiency syndrome.

Author: TaskintunaI, RahhalF M, ArevaloJ F, MunguiaD, BankerA S, De ClercqE, FreemanW R

Effective for CMV retinitis
Hypotony
Iritis

Intravitreal injections of 10 micrograms of cidofovir were found to be effective in treating cytomegalovirus retinitis, but may be associated with iritis and hypotony.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

3.

Histopathologic effects of cidofovir on cartilage.

Author: SpiegelJeffrey H, AndrusJennifer G, StefanatoCatherine M, HeerenTimothy

Respiratory papillomatosis treatment
Cartilage changes
Skin changes

A study evaluated the effects of subcutaneous cidofovir injections on cartilage in a rabbit model. Delayed skin changes and histopathologic changes in cartilage were observed in about one-third of the injection sites. Higher doses of cidofovir may be safe to use, but further research is needed to assess long-term effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Mucosal bridge and pitting of the true vocal fold: an unusual complication of cidofovir injection.

Author: ManLi-Xing, StathamMelissa M, RosenClark A

Papillomatosis treatment
Mucosal injury

This case report describes a unique complication of intralaryngeal cidofovir injection in a patient with recurrent respiratory papillomatosis. Repeated high-dose injections resulted in the formation of a mucosal bridge and a pit in the true vocal fold.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Is recurrent respiratory papillomatosis a manageable or curable disease?

Author: KimHyung-Tae, BaizhumanovaAigul Saparadievna

Improved voice quality
RRP remission

This study evaluated the patterns of recurrence of recurrent respiratory papillomatosis (RRP) after surgery and determined the effectiveness of combined concurrent adjuvant therapy. The most common subsites for recurrence were the anterior commissure, subglottis, and epiglottis. A combined treatment approach, including microlaryngeal surgery, pulsed dye laser application, and intralesional cidofovir injection, showed promising results in reducing recurrence rates and restoring vocal function.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Effectiveness of cidofovir intralesional treatment in recurrent respiratory papillomatosis.

Author: WierzbickaMałgorzata, JackowskaJoanna, BartochowskaAnna, JózefiakAgata, SzyfterWitold, KędziaWitold

Effective RRP treatment
Safe RRP treatment
Hepatic toxicity

This study presented results of recurrent respiratory papillomatosis (RRP) treatment with surgical excision and cidofovir intralesional use. Cidofovir was effective in 18 out of 32 patients and safe, and should be considered in those patients who experienced disease relapse.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Clinical failure of CMV retinitis with intravitreal cidofovir is associated with antiviral resistance.

Author: SmithI L, TaskintunaI, RahhalF M, PowellH C, AiE, MuellerA J, SpectorS A, FreemanW R

Cidofovir resistance

Clinical resistance to intraocular cidofovir injection for AIDS-related CMV retinitis occurred infrequently but was associated with prior ganciclovir or intravenous cidofovir use and resistant CMV strains.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

10.

[Intralesional cidofovir injections for recurrent laryngeal papillomatosis: first results].

Author: NeumannK, PudszuhnA, WelzelC, Bartel-FriedrichS, PassmannM

Cidofovir, a nucleoside analog, is being investigated as a treatment for recurrent laryngeal papillomatosis, a benign disease of the larynx caused by human papilloma virus (HPV) infection. Intralesional injection of cidofovir is being evaluated in pilot studies.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : German

11.

[Anti-viral injectable treatment (cidofovir) in laryngeal papillomatosis].

Author: CoulombeauB, Nusa NaimanA, CeruseP, FroehlichP

Laryngeal papillomatosis treatment
Vocal sequelae

Cidofovir endoscopy was performed in 26 patients with laryngeal papillomatosis. Total remission was achieved in 8 patients (31%) after between 2 and 8 interventions. 27 patients (65%) showed clinically significant partial remission.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

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