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Treatment with alendronate prevents fractures in women at highest risk: results from the Fracture Intervention Trial.

Author: Barrett-ConnorE, BauerD C, BlackD M, EnsrudK E, KarpfD B, PalermoL, QuandtS A, ThompsonD E

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Alendronate effectively reduces fracture risk in postmenopausal women with vertebral fractures and low bone mineral density, including those at highest risk due to advanced age or severe osteoporosis. The benefit of alendronate treatment was consistent across different risk categories, suggesting that treating high-risk women can prevent more fractures.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The efficacy of antiresorptive therapy in preventing fractures in women at highest fracture risk, such as very elderly women or those with severe osteoporosis, is uncertain. PARTICIPANTS AND METHODS: Using data from a double-blind, randomized, placebo-controlled clinical trial that enro...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9531231

データ提供：米国国立医学図書館（NLM）

Alendronate: Preventing Fractures in High-Risk Women

Osteoporosis, a condition characterized by weakened bones, is a significant public health concern, especially among postmenopausal women. This study investigates the effectiveness of alendronate, a bisphosphonate medication, in preventing fractures in women at highest risk, a group often considered challenging to treat. The study employed a double-blind, randomized, placebo-controlled trial, enrolling 2027 postmenopausal women with low femoral neck bone mineral density and existing vertebral fractures. The results revealed a significant reduction in the risk of new vertebral fractures and incident clinical fractures in the alendronate group compared to the placebo group. This discovery is like finding a hidden oasis in the desert of osteoporosis research, offering a potential solution for preventing fractures in high-risk women.

Alendronate: A Potential Solution for High-Risk Osteoporosis

The study's findings suggest that alendronate can be a valuable tool for preventing fractures in women at highest risk of osteoporosis. The research highlights the effectiveness of this medication in this challenging population, offering a beacon of hope for women struggling with this condition. This discovery is like finding a hidden oasis in the desert of osteoporosis research, offering a potential solution for preventing fractures in high-risk women.

Maintaining Bone Health

The study emphasizes the importance of early diagnosis and treatment of osteoporosis, especially in high-risk individuals. The findings encourage women at high risk to discuss treatment options with their healthcare providers, potentially preventing future fractures and maintaining overall bone health. The research highlights the importance of personalized medicine, considering the individual needs and risks of each patient.

Dr.Camel's Conclusion

This study provides valuable insights into the effectiveness of alendronate in preventing fractures in high-risk women with osteoporosis. It's like finding a hidden oasis in the vast desert of bone health research, offering a source of strength and resilience for women at high risk. This research encourages continued research and innovation in this area, ultimately improving the lives of millions of women worldwide.

Date :
  1. Date Completed 1998-04-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9531231

DOI: Digital Object Identifier

9531231

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Article Analysis
・Effective treatment of osteoporosis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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