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Safety and immunogenicity of live, attenuated human rotavirus vaccine 89-12.
Author: BernsteinD I, DeFeudisD, SanderD S, SchiffG M, SherwoodJ R, SmithV E, SpriggsD R, WardR L
Original Abstract of the Article :
The safety and immunogenicity of an orally administered live human rotavirus vaccine candidate (89-12), attenuated by 33 passages in monkey kidney cells, were evaluated in placebo-controlled trials in adults, children and infants. This strain was selected because natural infections with 89-12-like r...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1016/s0264-410x(97)00210-7
データ提供:米国国立医学図書館(NLM)
A Quest for Rotavirus Vaccine Safety and Immunogenicity
The quest for safe and effective vaccines against rotavirus, a common cause of severe diarrhea in infants, is a paramount concern in global health. This research delves into the safety and immunogenicity of a live, attenuated human rotavirus vaccine candidate (89-12), meticulously evaluated in controlled trials involving adults, children, and infants. The researchers aimed to assess the vaccine's ability to elicit an immune response while ensuring its safety for diverse populations.
Promising Results: Safety and Immunogenicity
The study's results provide encouraging evidence regarding the safety and immunogenicity of the 89-12 vaccine. No significant differences in side effects were observed between the vaccinated and placebo groups, indicating a favorable safety profile. The vaccine demonstrated seroconversion in a significant proportion of previously uninfected recipients, suggesting its ability to stimulate an immune response.
A Step Forward in Combating Rotavirus
This research underscores the importance of ongoing efforts to develop safe and effective vaccines for preventable diseases like rotavirus. The findings provide a foundation for further research and potential clinical applications, offering hope for reducing the global burden of rotavirus-related illness.
Dr.Camel's Conclusion
The relentless pursuit of scientific knowledge, much like the camel's journey across the vast desert, requires persistence and a commitment to finding solutions. This research, with its focus on vaccine safety and immunogenicity, serves as a testament to the unwavering dedication of researchers in protecting the health and well-being of individuals, particularly the most vulnerable, like infants. It's a journey that, if successful, could have a profound impact on the lives of countless people around the world.
Date :
- Date Completed 1998-07-23
- Date Revised 2019-07-28
Further Info :
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English
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