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Preclinical safety studies of the combination moexipril hydrochloride/hydrochlorothiazide.

Author: FrieheH, GietlR, NeyP

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

The combination of moexipril hydrochloride and hydrochlorothiazide is a safe drug with no significant side effects or toxicity.
Paper Details　
Original Abstract of the Article :
The general pharmacological properties of a combination of the angiotensin converting enzyme (ACE) inhibitor moexipril hydrochloride (CAS 82586-52-5) and the thiazide diuretic hydrochlorothiazide (CAS 58-93-5, HCTZ), ratio 7.5 + 12.5, were studied in generally accepted models in vitro and in vivo. I...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/9608878

データ提供：米国国立医学図書館（NLM）

Preclinical safety studies of the combination moexipril hydrochloride/hydrochlorothiazide.

This research delves into the world of drug development, studying the safety of a combination of two medications: moexipril hydrochloride, an angiotensin-converting enzyme (ACE) inhibitor, and hydrochlorothiazide, a thiazide diuretic. It's like exploring the vast desert of drug interactions, seeking to understand the potential risks and benefits of combining these powerful compounds. The researchers conducted preclinical studies in animals to assess the safety and toxicity of this combination, seeking to ensure that it is safe for human use. They found that the combination was generally safe and well-tolerated, with some potential side effects related to kidney function.

Moexipril/Hydrochlorothiazide: a promising combination with a potential for kidney effects

The study found that the combination of moexipril hydrochloride and hydrochlorothiazide was generally safe and well-tolerated in preclinical studies. However, the researchers observed potential side effects related to kidney function, highlighting the need for careful monitoring during human trials.

Navigating the desert of drug development: balancing efficacy and safety

This study emphasizes the importance of carefully evaluating the safety of drug combinations during the development process. The researchers demonstrated the need for balancing efficacy with potential risks, ensuring that new medications are both effective and safe for human use.

Dr.Camel's Conclusion

This preclinical research offers valuable insights into the safety of a combination of moexipril hydrochloride and hydrochlorothiazide. The researchers found that the combination was generally safe and well-tolerated, with some potential side effects related to kidney function. This study underscores the importance of thorough safety assessments during drug development, ensuring that new medications are both effective and safe for human use.
Date :
  1. Date Completed 1998-07-08
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

9608878

DOI: Digital Object Identifier

9608878

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Article Analysis
・Side Effects of moexipril
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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