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A comparison of rectal diazepam gel and placebo for acute repetitive seizures.

Author: BellW E, BergenD C, CloydJ C, ConryJ A, DreifussF E, KuznieckyR I, LoW D, MatsuoF, PellockJ M, RosmanN P, SharpG B

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Rectal diazepam gel is an effective and well-tolerated treatment for acute repetitive seizures when administered at home by trained caregivers. Diazepam treatment is superior to placebo in reducing seizure frequency and improving overall outcome in both children and adults.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Acute repetitive seizures are readily recognizable episodes involving increased seizure frequency. Urgent treatment is often required. Rectal diazepam gel is a promising therapy. METHODS: We conducted a randomized, double-blind, parallel-group, placebo-controlled study of home-based tre...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM199806253382602

データ提供：米国国立医学図書館（NLM）

Rectal Diazepam Gel for Acute Repetitive Seizures: A Promising Home-Based Treatment

The world of epilepsy is a challenging one, often characterized by unpredictable seizures that can disrupt daily life. Acute repetitive seizures, a condition marked by increased seizure frequency, can be particularly distressing and require urgent medical attention.

This study investigates the effectiveness of rectal diazepam gel as a home-based treatment for acute repetitive seizures. Diazepam is a medication that can effectively reduce seizure activity, and the rectal route of administration offers a convenient and potentially safer alternative to intravenous administration.

The study compares the effectiveness of rectal diazepam gel to placebo in a randomized, double-blind, placebo-controlled trial, evaluating the number of seizures, treatment outcome, and adverse effects. The findings suggest that rectal diazepam gel is an effective and well-tolerated treatment for acute repetitive seizures, providing a valuable home-based option for managing this condition.

Expanding Treatment Options for Epilepsy: Bringing Relief to Patients at Home

This study demonstrates the potential of rectal diazepam gel as a safe and effective home-based treatment for acute repetitive seizures. This could expand access to effective treatment for those experiencing this challenging condition, providing them with greater control over their health and well-being.

Navigating the Labyrinth of Epilepsy: A Journey Through the Desert of Seizures

This research highlights the importance of developing effective and accessible treatment options for epilepsy. Like a camel navigating a labyrinth of seizures, we must find ways to provide relief and improve the quality of life for those living with this condition.

Dr.Camel's Conclusion

This study underscores the potential of rectal diazepam gel as a valuable home-based treatment for acute repetitive seizures. Like a wise camel seeking a safe haven from a desert storm, epilepsy patients may find comfort and relief through this effective and accessible treatment option.

Date :
  1. Date Completed 1998-06-25
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

9637805

DOI: Digital Object Identifier

10.1056/NEJM199806253382602

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・Effective treatment of seizures
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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