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Evaluation of intramuscular 15(s)-15-methyl prostaglandin F2 alpha tromethamine salt for induction of abortion, medications to attenuate side effects, and intracervical laminaria tents.

Author: BrennerW E, DingfelderJ R, GruberW, StaurovskyL G, WellsJ S

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

15(S)-15-methyl prostaglandin F2alpha tromethamine was found to be effective in inducing abortion in gravidas 8 to 20 menstrual weeks' gestation.
Paper Details　
Original Abstract of the Article :
Sixty gravidas 8 to 20 menstrual weeks' gestation were studied to evaluate (1) the efficacy of intramuscularly administered 15(S)-15-methyl prostaglandin F2alpha tromethamine (15(S)-Me-PGF2alpha) as an abortifacient; (2) the effectiveness of prochlorperazine and Lomotil for attenuation of vomiting a...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/964392

データ提供：米国国立医学図書館（NLM）

Evaluation of intramuscular 15(s)-15-methyl prostaglandin F2 alpha tromethamine salt for induction of abortion, medications to attenuate side effects, and intracervical laminaria tents

This research investigates the efficacy of intramuscularly administered 15(S)-15-methyl prostaglandin F2alpha tromethamine (15(S)-Me-PGF2alpha) as an abortifacient, exploring its effectiveness, side effects, and potential for augmentation with intracervical laminaria tents.

15(S)-Me-PGF2alpha Effective in Inducing Abortion

The study's findings demonstrate that 15(S)-Me-PGF2alpha is effective in inducing abortion in gravidas between 8 and 20 menstrual weeks' gestation. The administration of the prostaglandin resulted in a significant decrease in body temperature and successful abortion induction. However, the study also found that the regimen of prochlorperazine and Lomotil for attenuating vomiting and diarrhea was only partially effective, significantly reducing only diarrhea.

Considerations for Prostaglandin-Based Abortion

This research provides valuable insights into the use of 15(S)-Me-PGF2alpha for abortion induction. The study's findings highlight the effectiveness of this prostaglandin, while acknowledging the challenges in managing associated side effects. The study also demonstrates the limited effectiveness of laminaria augmentation for enhancing the prostaglandin dose schedule. The desert of reproductive healthcare is vast and often complex, and research like this helps to guide our understanding of safe and effective abortion methods.

Dr.Camel's Conclusion

This study provides valuable information regarding the efficacy of 15(S)-Me-PGF2alpha for abortion induction. The findings demonstrate the effectiveness of this prostaglandin, while highlighting the challenges in managing associated side effects and the limited effectiveness of laminaria augmentation. This research provides valuable insights into the use of prostaglandins for abortion induction, helping to inform clinical practice and patient care.

Date :
  1. Date Completed 1976-11-21
  2. Date Revised 2017-09-20
Further Info :

Pubmed ID

964392

DOI: Digital Object Identifier

S0015-0282(16)42069-8

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