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Combination of PUVAsol and topical calcipotriol in vitiligo.

Author: ParsadD, SainiR, VermaN

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

While many treatments exist for vitiligo, psoralens remain a common option despite inconsistent effectiveness. Recent research has linked vitiligo to disrupted calcium levels in the skin and found that melanocytes (pigment-producing cells) have receptors for vitamin D3. This suggests that vitamin D3 might play a role in vitiligo treatment.
Paper Details　
Original Abstract of the Article :
A large variety of therapeutic agents are being tried for the treatment of vitiligo, but psoralens continue to be mainstay of treatment although they are not uniformly effective. Recent advances in pathophysiology have established a perturbed calcium homeostasis in affected skin, and melanocytes wer...See full text at original site
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引用元：
https://doi.org/10.1159/000017991

データ提供：米国国立医学図書館（NLM）

Exploring the Combination of PUVAsol and Topical Calcipotriol for Vitiligo

This research explores a novel combination therapy for vitiligo, a skin condition characterized by depigmentation. The study focuses on combining PUVAsol, a psoralen-based photochemotherapy, with topical calcipotriol, a vitamin D3 analog. The researchers' interest in this combination stems from recent advances in understanding the pathophysiology of vitiligo, particularly the role of calcium homeostasis and vitamin D3 receptors in melanocytes. The study aims to investigate the potential synergistic effects of this combination therapy in promoting repigmentation.

New Frontiers in Vitiligo Treatment: Combining Therapies for Optimal Results

This research highlights the search for innovative treatment strategies for vitiligo, a challenging condition that can significantly impact a person's quality of life. The study's exploration of a novel combination therapy involving PUVAsol and topical calcipotriol offers hope for new and potentially more effective treatment options.

A Holistic Approach to Skin Health: Understanding the Complexities of Vitiligo

This research emphasizes the need for a comprehensive understanding of vitiligo's pathophysiology to develop targeted and effective treatments. The study's focus on the role of calcium homeostasis and vitamin D3 receptors in melanocytes highlights the interconnectedness of various biological pathways and their impact on skin health.

Dr. Camel's Conclusion

This research offers a promising new direction in the treatment of vitiligo, exploring the potential of combining PUVAsol with topical calcipotriol. The study's findings suggest that this combination therapy may hold promise for promoting repigmentation and improving treatment outcomes for patients with vitiligo. Further research is essential to confirm these findings and optimize the use of this combination therapy in clinical practice. The journey towards more effective vitiligo treatments is ongoing, and this research offers hope for a brighter future for individuals living with this condition.

Date :
  1. Date Completed 1998-11-10
  2. Date Revised 2018-02-13
Further Info :

Pubmed ID

9732168

DOI: Digital Object Identifier

10.1159/000017991

Related Literature

Article Analysis
・Effective treatment of vitiligo
SNS
PICO Info
in preparation
Languages

English

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