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Effect of tamoxifen and transdermal hormone replacement therapy on cardiovascular risk factors in a prevention trial. Italian Chemoprevention Group.

Author: BoyleP, CostaA, DecensiA, MaisonneuveP, RobertsonC, RotmenszN, SacchiniV, SeveriG, VeronesiU

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Tamoxifen's beneficial effects on cardiovascular risk factors were not altered in women currently using hormone replacement therapy (HRT). However, starting transdermal HRT while on tamoxifen may attenuate these benefits. These findings suggest that tamoxifen can be safely used in women currently on HRT, but caution is needed when starting HRT while on tamoxifen.
Paper Details　
Original Abstract of the Article :
The combination of tamoxifen and transdermal hormone replacement therapy (HRT) may potentially reduce risks and side-effects of either agent, but an adverse interaction could attenuate their beneficial effects. We assessed the effects of their combination on cardiovascular risk factors within a prev...See full text at original site
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引用元：
https://doi.org/10.1038/bjc.1998.542

データ提供：米国国立医学図書館（NLM）

Tamoxifen and Hormone Replacement Therapy: A Balancing Act

The combination of tamoxifen and hormone replacement therapy (HRT) can be a balancing act, like navigating a delicate ecosystem in a desert. This study examines the effects of this combination on cardiovascular risk factors, exploring the potential benefits and risks of this treatment approach. It's like studying the delicate balance of a desert ecosystem, where every element plays a role in maintaining the overall health of the environment.

A Complex Interplay of Medications

The study found that tamoxifen's beneficial effects on cardiovascular risk factors were unchanged in women already on HRT. However, these effects might be attenuated in women who start HRT while on tamoxifen. This is like observing the interplay of different plants and animals in a desert ecosystem, where the introduction of a new species can have unexpected consequences.

Weighing the Benefits and Risks

The study suggests that further research is needed to understand the interplay of tamoxifen and HRT on cardiovascular risk factors. It's important to carefully consider the potential benefits and risks of this combination before making treatment decisions. This is like considering the potential impacts of introducing a new species into a delicate desert ecosystem, weighing the potential benefits against the potential risks.

Dr. Camel's Conclusion

This study highlights the importance of careful consideration when combining tamoxifen and HRT. It's a reminder that the desert of medical research is full of complexities, and we must navigate these complexities with caution and a keen understanding of the interactions between different elements.

Date :
  1. Date Completed 1998-09-24
  2. Date Revised 2019-05-15
Further Info :

Pubmed ID

9744493

DOI: Digital Object Identifier

10.1038/bjc.1998.542

Related Literature

Article Analysis
・Effects of tamoxifen
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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