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Effects of the serotonin1B/1D receptor agonist zolmitriptan on motor cortical excitability in humans.

Author: FörderreutherS, StraubeA, WerhahnK J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Zolmitriptan, a 5-hydroxytriptamine receptor agonist, reduced motor cortical excitability in healthy volunteers. This effect is thought to be mediated by the influence of zolmitriptan on GABAergic inhibitory interneurons within the motor cortex.
Paper Details　
Original Abstract of the Article :
Oral administration of zolmitriptan, a novel 5-hydroxytriptamine receptor agonist, to eight healthy volunteers significantly reduced motor cortical excitability as tested by paired transcranial magnetic stimulation (TMS) at short interstimulus intervals. Zolmitriptan did not change motor thresholds ...See full text at original site
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引用元：
https://doi.org/10.1212/wnl.51.3.896

データ提供：米国国立医学図書館（NLM）

Zolmitriptan: A Serotonin Receptor Agonist with Effects on Motor Cortex

Migraines, debilitating headaches, can significantly impact an individual's quality of life. This study investigates the effects of zolmitriptan, a serotonin1B/1D receptor agonist, on motor cortical excitability in humans. The researchers employed paired transcranial magnetic stimulation (TMS) to assess motor cortical excitability before and after administering zolmitriptan to healthy volunteers. The results indicate that zolmitriptan significantly reduced motor cortical excitability, suggesting that its action may involve modulation of inhibitory processes within the motor cortex.

Zolmitriptan: A Multifaceted Approach to Migraine Relief

This study offers valuable insights into the mechanism of action of zolmitriptan, suggesting that its effects extend beyond simply relieving migraine symptoms. By demonstrating its influence on motor cortical excitability, the research provides a deeper understanding of the drug's potential benefits and potential implications for treatment strategies.

Migraines: A Journey Through the Labyrinth of Pain

Migraines can be like a desert sandstorm, a relentless assault on your senses that leaves you disoriented and overwhelmed. This study sheds light on the potential of zolmitriptan to manage migraine pain and explore the intricate pathways involved. Understanding the complex interplay of neurotransmitters and brain activity is crucial for developing effective treatments and empowering individuals to navigate this challenging journey.

Dr.Camel's Conclusion

This research sheds light on the effects of zolmitriptan, a serotonin receptor agonist, on motor cortical excitability in humans. The study's findings suggest that zolmitriptan's action may involve modulation of inhibitory processes within the motor cortex. This understanding could lead to a more comprehensive approach to managing migraine pain and improving patient outcomes.

Date :
  1. Date Completed 1998-10-20
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

9748054

DOI: Digital Object Identifier

10.1212/wnl.51.3.896

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in preparation
Languages

English

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