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Porcine carotid vascular effects of eletriptan (UK-116,044): a new 5-HT1B/1D receptor agonist with anti-migraine activity.

Author: De VriesP, HeiligersJ P, SaxenaP R, WillemsE

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Eletriptan, a triptan medication used to treat migraines, was found to constrict cephalic arteriovenous anastomoses, which are thought to play a role in migraines. This effect was mediated by 5-HT1B/1D receptors. The constriction of cephalic arteriovenous anastomoses may contribute to the efficacy of eletriptan in treating migraines.
Paper Details　
Original Abstract of the Article :
It has been suggested that opening of cephalic arteriovenous anastomoses may be involved in the headache phase of migraine. Indeed, a number of acutely acting anti-migraine drugs, including the ergot alkaloids and sumatriptan, constrict porcine carotid arteriovenous anastomoses. In this study, using...See full text at original site
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引用元：
https://doi.org/10.1007/pl00005245

データ提供：米国国立医学図書館（NLM）

Eletriptan: A New Oasis for Migraine Relief

Migraine headaches are a debilitating condition that can feel like a scorching desert storm. Finding effective treatments is like searching for a cool breeze in the midst of the chaos. This study explores the effects of eletriptan, a new drug designed to combat migraine headaches, on the blood vessels of the head.

The researchers used anesthetized pigs to study the effects of eletriptan on the blood flow distribution in the carotid arteries. They focused on the arteriovenous anastomoses, tiny connections between arteries and veins that play a role in migraine headaches.

Eletriptan: A Cooling Effect on the Desert Storm

The study found that eletriptan selectively constricted the arteriovenous anastomoses, suggesting that it may be effective in treating migraine headaches. It also increased blood flow to the tissues of the head, potentially enhancing the delivery of nutrients and oxygen to the affected areas.

Finding Relief in the Desert of Migraine

This study offers a glimmer of hope for people suffering from migraines, suggesting that eletriptan may be a valuable tool in managing this debilitating condition. The study also highlights the importance of understanding the complex interplay between blood flow, vascular function, and migraine headaches.

Dr.Camel's Conclusion

This study presents a promising new medication for migraine headaches, offering a possible oasis of relief in the midst of the desert storm. The study’s findings encourage further research into the mechanisms of migraine and the potential therapeutic applications of eletriptan.

Date :
  1. Date Completed 1998-12-04
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

9750007

DOI: Digital Object Identifier

10.1007/pl00005245

Related Literature

Article Analysis
・Effects of eletriptan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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