Paper Details

  1. Home
  2. Paper Details

The importance of initial daily administration of interferon alpha for the eradication of hepatitis C virus in patients with chronic hepatitis C: a multicenter randomized trial.

Author: HaradaH, HayashiE, IgarashiA, InadaM, ItoH, KanazawaS, KimuraY, KishimotoT, KobayashiY, KurodaT, NakamuraH, OgawaH, SaekiK, TakedaA, TerabayashiM, UemiyaM, WadaM, ZendaS

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.

Overview

This study found that initial daily interferon administration is necessary to gain a higher rate of serum HCV-RNA eradication in patients with chronic hepatitis C.
Paper Details　
Original Abstract of the Article :
BACKGROUND/AIMS: We studied the effect of initial daily administration of interferon for the treatment of chronic hepatitis C, to clarify a more effective treatment protocol for the eradication of the hepatitis C virus. METHODOLOGY: Consecutive patients who met the inclusion criteria were randomly ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/9756005

データ提供：米国国立医学図書館（NLM）

Interferon Alpha: A Key to Eradicating Hepatitis C

The field of hepatitis C research has seen significant advancements in understanding the disease and developing effective treatments. This study explores the importance of initial daily administration of interferon alpha for the eradication of hepatitis C virus (HCV) in patients with chronic hepatitis C. The authors conducted a multicenter randomized trial to compare the effectiveness of daily interferon alpha administration for the initial two weeks followed by thrice-weekly administration with thrice-weekly administration throughout the treatment course.

Initial Daily Interferon Alpha: A Crucial Step in HCV Eradication

The study found that patients receiving initial daily interferon alpha administration had a significantly higher rate of HCV eradication compared to those receiving thrice-weekly administration throughout the treatment course. The findings suggest that the initial daily administration strategy is crucial for achieving sustained viral response and maximizing treatment success.

Health Implications

This study provides valuable guidance for clinicians managing patients with chronic hepatitis C, highlighting the importance of initial daily interferon alpha administration for optimizing treatment outcomes. The findings underscore the need for individualized treatment strategies tailored to each patient's needs and viral genotype.

Dr.Camel's Conclusion

This study offers a valuable insight into the effective management of hepatitis C, emphasizing the critical role of initial daily interferon alpha administration in maximizing viral eradication. The findings serve as a guide for clinicians to optimize treatment strategies and improve patient outcomes in the battle against this chronic viral infection.

Date :
  1. Date Completed 1998-12-09
  2. Date Revised 2004-11-17
Further Info :

Pubmed ID

9756005

DOI: Digital Object Identifier

9756005

Related Literature

Article Analysis
・Effective treatment of hepatitis c
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.