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Systemic bioactivity profiles of oral prednisolone and nebulized budesonide in adult asthmatics.

Author: LipworthB J, McFarlaneL C, WilsonA M

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

For all three systemic bioactivity markers (8 AM plasma cortisol, serum osteocalcin, and blood eosinophils), there was significant dose-related suppression with prednisolone but not with budesonide. In a study of 12 asthmatic patients, regression analysis showed significant dose-related suppression with prednisolone for 8 AM plasma cortisol, osteocalcin, and blood eosinophil count, but not with budesonide.
Paper Details　
Original Abstract of the Article :
STUDY OBJECTIVE: Because nebulized budesonide may be used as an alternative to maintenance oral prednisolone in the treatment of severe chronic asthma, it is important to compare these two drugs to determine their relative systemic bioactivity profiles in terms of effects on adrenal, bone, and hemat...See full text at original site
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引用元：
https://doi.org/10.1378/chest.114.4.1022

データ提供：米国国立医学図書館（NLM）

Comparing Systemic Bioactivity of Oral Prednisolone and Nebulized Budesonide: A Journey Through the Desert of Asthma

Asthma is a complex respiratory condition, like a desert that can be difficult to navigate, often causing shortness of breath and other symptoms. This study compares the systemic bioactivity profiles of oral prednisolone and nebulized budesonide, two commonly used medications for asthma treatment. The researchers aimed to understand the relative effects of these medications on various biological markers, providing valuable insights into their safety and efficacy.

Nebulized Budesonide: A Safer Path Through the Asthma Desert

This study offers a valuable comparison of two asthma medications, revealing important differences in their systemic effects. The researchers found that prednisolone had a significant impact on various biomarkers, indicating a greater potential for systemic side effects. In contrast, nebulized budesonide had a much more localized effect, suggesting a potentially safer approach for managing asthma. It's like finding a hidden spring of water that offers a less disruptive and potentially more sustainable source of relief.

Navigating the Asthma Desert: Choosing the Right Treatment Approach

It's crucial to work with a healthcare professional to determine the best treatment approach for asthma. The choice of medication should be individualized, taking into account the patient's specific needs and response to treatment. It's like choosing the right camel for a desert journey, ensuring that your mode of transportation is well-suited to the challenges ahead. This research provides valuable insights into the safety and efficacy of different asthma medications, guiding clinicians and patients toward more informed treatment decisions.

Dr.Camel's Conclusion

This study underscores the importance of careful consideration when choosing asthma medications, taking into account their systemic effects and individual patient characteristics. It’s a reminder that the desert of asthma treatment is vast and complex, requiring careful navigation and a commitment to finding the right path for each patient.
Date :
  1. Date Completed 1998-11-06
  2. Date Revised 2019-05-14
Further Info :

Pubmed ID

9792571

DOI: Digital Object Identifier

10.1378/chest.114.4.1022

Related Literature

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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